U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Det1 DET1 partner of COP1 E3 ubiquitin ligase [ Mus musculus (house mouse) ]

    Gene ID: 76375, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Det1provided by MGI
    Official Full Name
    DET1 partner of COP1 E3 ubiquitin ligaseprovided by MGI
    Primary source
    MGI:MGI:1923625
    See related
    Ensembl:ENSMUSG00000030610 AllianceGenome:MGI:1923625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610034H20Rik
    Summary
    Predicted to enable ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human DET1 (DET1 partner of COP1 E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.1), ovary adult (RPKM 5.8) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Det1 in Genome Data Viewer
    Location:
    7 44.81 cM; 7 D2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (78471293..78497272, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (78821545..78847524, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:85927896-85928197 Neighboring gene mitochondrial ribosomal protein L46 Neighboring gene mitochondrial ribosomal protein S11 Neighboring gene STARR-seq mESC enhancer starr_19254 Neighboring gene STARR-seq mESC enhancer starr_19255 Neighboring gene predicted gene, 57212 Neighboring gene STARR-seq mESC enhancer starr_19256 Neighboring gene microRNA 7-2 Neighboring gene predicted gene, 39039

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Role of Arabidopsis ABF1/3/4 during det1 germination in salt and osmotic stress conditions. Fernando VCD, et al. Plant Mol Biol, 2018 May. PMID 29680877
    2. Transcription factor Etv5 is essential for the maintenance of alveolar type II cells. Zhang Z, et al. Proc Natl Acad Sci U S A, 2017 Apr 11. PMID 28351980, Free PMC Article
    3. Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain. Newton K, et al. Proc Natl Acad Sci U S A, 2018 Oct 30. PMID 30322923, Free PMC Article
    4. Cryptochromes-Mediated Inhibition of the CRL4(Cop1)-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism. Rizzini L, et al. Curr Biol, 2019 Jun 17. PMID 31155351, Free PMC Article
    5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DET1 homolog
    Names
    de-etiolated homolog 1
    de-etiolated-1 homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419047.1 → NP_001405976.1  DET1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    2. NM_001419048.1 → NP_001405977.1  DET1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    3. NM_001419049.1 → NP_001405978.1  DET1 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    4. NM_001419050.1 → NP_001405979.1  DET1 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    5. NM_029585.4 → NP_083861.1  DET1 homolog isoform 1

      See identical proteins and their annotated locations for NP_083861.1

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556
      Consensus CDS
      CCDS21375.1
      UniProtKB/Swiss-Prot
      Q9D0A0
      Related
      ENSMUSP00000032839.7, ENSMUST00000032839.13
      Conserved Domains (1) summary
      pfam09737
      Location:142 → 546
      Det1; De-etiolated protein 1 Det1

    RNA

    1. NR_185006.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    2. NR_185007.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    3. NR_185008.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    4. NR_185009.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    5. NR_185010.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    6. NR_185011.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    7. NR_185012.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138376, AC156556

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      78471293..78497272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243076.2 → XP_030098936.1  DET1 homolog isoform X3

      Conserved Domains (1) summary
      pfam09737
      Location:142 → 488
      Det1; De-etiolated protein 1 Det1

    2. XM_006541269.4 → XP_006541332.1  DET1 homolog isoform X4

      Conserved Domains (1) summary
      pfam09737
      Location:142 → 487
      Det1; De-etiolated protein 1 Det1

    RNA

    1. XR_004934203.1 RNA Sequence

    2. XR_004934200.1 RNA Sequence

    3. XR_004934202.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0A0.2 GenPept UniProtKB/Swiss-Prot:Q9D0A0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous