Pla1a phospholipase A1 member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla1aprovided by MGI
Official Full Name: phospholipase A1 member Aprovided by MGI
Primary source: MGI:MGI:1934677
See related: Ensembl:ENSMUSG00000002847 AllianceGenome:MGI:1934677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pspla1; Ps-pla1
Summary: Enables phospholipase A1 activity. Predicted to be involved in lipid catabolic process. Predicted to act upstream of or within lipid metabolic process. Located in acrosomal membrane. Is expressed in adrenal gland; alimentary system; gland; and liver. Orthologous to human PLA1A (phospholipase A1 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 27.9), mammary gland adult (RPKM 23.4) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 26.83 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (38214245..38253553, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (38396117..38433191, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A phosphatidic acid-phospholipase A1alpha-lysophosphatidic acid-P2Y5 axis regulates differentiation of hair follicles via a tumour necrosis factor alpha converting enzyme-transforming growth factor alpha-epidermal growth factor receptor pathway.
Title: LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Markers

Pla1a (e-PCR), detects polymorphism
- UniSTS:507145

Pspla1-pending (e-PCR), detects polymorphism
- UniSTS:226076

D16Mit59 (e-PCR), detects polymorphism
- UniSTS:127893

AA986889 (e-PCR)
- UniSTS:163574

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phospholipase A1 member A

Names: phosphatidylserine-specific phospholipase A1

NP_598863.3

EC 3.1.1.111

XP_006522834.1

EC 3.1.1.111

XP_006522835.1

EC 3.1.1.111

XP_006522837.1

EC 3.1.1.111

XP_036016082.1

EC 3.1.1.111

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.