Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aldh1a7provided by MGI
Official Full Name: aldehyde dehydrogenase family 1, subfamily A7provided by MGI
Primary source: MGI:MGI:1347050
See related: Ensembl:ENSMUSG00000024747 AllianceGenome:MGI:1347050
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aldhpb; Aldh-pb; Aldh1a4; Ahd2-like
Summary: Predicted to enable identical protein binding activity and oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Predicted to be involved in cellular detoxification of aldehyde and fructosamine catabolic process. Predicted to be located in cytosol. Is expressed in liver; metanephros; ovary; testis; and urogenital ridge. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 37.2), liver adult (RPKM 30.8) and 8 other tissues See more
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Genomic context

Location:: 19 B; 19 13.95 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (20670318..20704920, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (20692953..20727556, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Aldh1a1 (e-PCR), detects polymorphism
- UniSTS:470549

Aldh1a7 (e-PCR), detects polymorphism
- UniSTS:525880

AI987940 (e-PCR)
- UniSTS:166131

Aldh1a7 (e-PCR), detects polymorphism
- UniSTS:507380

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-deoxyglucosone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info	PubMed
enables benzaldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables benzaldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of aldehyde	ISO Inferred from Sequence Orthology more info
involved_in fructosamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructose catabolic process	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within retinoic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldehyde dehydrogenase, cytosolic 1

Names: ALDH class 1; ALDH-E1; ALHDII; Aldehyde dehydrogenase 1 (phenobarbitol inducible); aldehyde dehydrogenase family 1 member A7; aldehyde dehydrogenase family 1, subfamily A4; aldehyde dehydrogenase phenobarbital-inducible

NP_036051.1

EC 1.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011921.3 → NP_036051.1 aldehyde dehydrogenase, cytosolic 1

See identical proteins and their annotated locations for NP_036051.1

Status: VALIDATED

Source sequence(s)

AC162458

Consensus CDS

CCDS29696.1

UniProtKB/Swiss-Prot

O35945, Q80ZX7

UniProtKB/TrEMBL

B2RTL5

Related

ENSMUSP00000025656.4, ENSMUST00000025656.4

Conserved Domains (1) summary

cd07141
Location:15 → 494

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like