Ces1c carboxylesterase 1C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ces1cprovided by MGI
Official Full Name: carboxylesterase 1Cprovided by MGI
Primary source: MGI:MGI:95420
See related: Ensembl:ENSMUSG00000057400 AllianceGenome:MGI:95420
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ee1; Es1; Es4; EsN; Ee-1; Es-4; Es-N; PESN; Ces-N
Summary: Enables carboxylic ester hydrolase activity. Acts upstream of or within response to bacterium. Located in extracellular space. Is expressed in several structures, including alimentary system; liver; nose; respiratory system; and urinary system. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward liver adult (RPKM 843.5) See more
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Genomic context

Location:: 8 C5; 8 44.99 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (93825643..93857911, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (93099015..93131283, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development.
Title: Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development.
Delayed midazolam dose effects against soman in male and female plasma carboxylesterase knockout mice.
Title: Delayed midazolam dose effects against soman in male and female plasma carboxylesterase knockout mice.
Phospho-non-steroidal anti-inflammatory drugs hydrolysis in wild-type mouse plasma was 6-530-fold higher than that in the plasma of Ces1c-/- mice.
Title: Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: implications for their clinical pharmacology.
Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels
Title: Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.
carboxylesterase I controls RhoA methylation
Title: Control of RhoA methylation by carboxylesterase I.
These results identify and characterize ES1 as a novel transcriptional regulator of GHR gene expression.
Title: Esterase 1 is a novel transcriptional repressor of growth hormone receptor gene expression: a unique noncatalytic role for a carboxyesterase protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (1)
Not Applicable (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables carboxylesterase activity	ISO Inferred from Sequence Orthology more info
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity, acting on ester bonds	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sterol esterase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to cholesterol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in organic substance catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in organic substance catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carboxylesterase 1C

Names: PES-N; esterase 1; liver carboxylesterase N; lung surfactant convertase

NP_031980.2

EC 3.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007954.4 → NP_031980.2 carboxylesterase 1C precursor

See identical proteins and their annotated locations for NP_031980.2

Status: VALIDATED

Source sequence(s)

AA286207, AC121985, AI047526, AI116924, AI527022

Consensus CDS

CCDS22527.1

UniProtKB/Swiss-Prot

E9QQ07, O54936, P11374, P23953, Q8K125

Related

ENSMUSP00000034189.9, ENSMUST00000034189.17

Conserved Domains (2) summary

COG0657
Location:121 → 234

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

cd00312
Location:25 → 525

Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...