Prokr2 prokineticin receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prokr2provided by MGI
Official Full Name: prokineticin receptor 2provided by MGI
Primary source: MGI:MGI:2181363
See related: Ensembl:ENSMUSG00000050558 AllianceGenome:MGI:2181363
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PKR2; Gpr73l1; Gpcr73l1; EG-VEGRF2; B830005M06Rik
Summary: Predicted to enable G protein-coupled receptor activity. Acts upstream of or within circadian rhythm. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; forelimb bud; hemolymphoid system gland; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 3 with or without anosmia. Orthologous to human PROKR2 (prokineticin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 1.4), CNS E18 (RPKM 1.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F2; 2 64.15 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (132211625..132227413, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (132369705..132385502, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypic and genotypic landscape of PROKR2 in neuroendocrine disorders.
Title: Phenotypic and genotypic landscape of PROKR2 in neuroendocrine disorders.
Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2.
Title: Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
Pressure Overload-Mediated Sustained PKR2 (Prokineticin-2 Receptor) Signaling in Cardiomyocytes Contributes to Cardiac Hypertrophy and Endotheliopathies.
Title: Pressure Overload-Mediated Sustained PKR2 (Prokineticin-2 Receptor) Signaling in Cardiomyocytes Contributes to Cardiac Hypertrophy and Endotheliopathies.
Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.
Title: Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.
The regulatory G protein signaling complex, Gbeta5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.
Title: The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.
The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons.
Title: The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons.
infiltrating neutrophils and 4T1 cells abundantly expressed prokineticin-2 (Prok2) and its receptor, Prokr1, respectively. Finally, the administration of 5-FU after the resection of the primary tumor failed to augment lung metastasis in the mice receiving Prokr1-deleted 4T1 cells.
Title: Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.
The sexually dimorphic pattern of Prokr2 expression indicates differential roles in reproductive function and, potentially, in other physiological systems.
Title: Sexually dimorphic distribution of Prokr2 neurons revealed by the Prokr2-Cre mouse model.
This study presents the first experimental evidence indicating a molecular interaction between anosmin 1 and PKR2. A truncated anosmin 1 protein comprising the first three domains of the protein interacts with the second extracellular loop of PKR2, involved in PK2 binding.
Title: Anosmin 1 Interacts with the Prokineticin Receptor 2 In Vitro Indicating a Molecular Link Between Both Proteins in the Pathogenesis of Kallmann Syndrome.
Data show that the prokineticins and their receptors PROK2, PKR1 and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease.
Title: Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (5) 1 citation

General gene information

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Markers

Prokr2 (e-PCR), detects polymorphism
- UniSTS:464676

D2Mit257 (e-PCR), detects polymorphism
- UniSTS:129138

Prokr2 (e-PCR), detects polymorphism
- UniSTS:527506

Gpr73l1 (e-PCR), detects polymorphism
- UniSTS:257004

D2Dcr75 (e-PCR), detects polymorphism
- UniSTS:507634

Prokr2 (e-PCR), detects polymorphism
- UniSTS:528635

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prokineticin receptor 2

Names: G protein-coupled receptor 73-like 1; PK-R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144944.3 → NP_659193.3 prokineticin receptor 2

See identical proteins and their annotated locations for NP_659193.3

Status: VALIDATED

Source sequence(s)

AL807793, BB844646, BC043116

Consensus CDS

CCDS16773.1

UniProtKB/Swiss-Prot

A2AMQ8, Q80XQ0, Q8BIR4, Q8K458

UniProtKB/TrEMBL

Q6GTF8

Related

ENSMUSP00000056659.8, ENSMUST00000049997.14

Conserved Domains (1) summary

cd15204
Location:51 → 341

7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

132211625..132227413 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239558.4 → XP_011237860.1 prokineticin receptor 2 isoform X3

UniProtKB/TrEMBL

E0CY28

Related

ENSMUSP00000124526.2, ENSMUST00000142766.2

Conserved Domains (2) summary

cd14964
Location:5 → 26

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 180

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_011239555.3 → XP_011237857.1 prokineticin receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011237857.1

UniProtKB/Swiss-Prot

A2AMQ8, Q80XQ0, Q8BIR4, Q8K458

UniProtKB/TrEMBL

Q6GTF8

Related

ENSMUSP00000105784.2, ENSMUST00000110156.2

Conserved Domains (1) summary

cd15204
Location:51 → 341

7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011239557.3 → XP_011237859.1 prokineticin receptor 2 isoform X2

Conserved Domains (2) summary

cd14964
Location:66 → 87

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:50 → 241

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily