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    Ppm1j protein phosphatase 1J [ Mus musculus (house mouse) ]

    Gene ID: 71887, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppm1jprovided by MGI
    Official Full Name
    protein phosphatase 1Jprovided by MGI
    Primary source
    MGI:MGI:1919137
    See related
    Ensembl:ENSMUSG00000002228 AllianceGenome:MGI:1919137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ppp2cz; PP2Czeta; 2310008J22Rik
    Summary
    Enables protein serine/threonine phosphatase activity. Acts upstream of or within protein dephosphorylation. Is expressed in dorsal root ganglion; lower jaw molar; telencephalon mantle layer; trigeminal ganglion; and upper jaw molar. Orthologous to human PPM1J (protein phosphatase, Mg2+/Mn2+ dependent 1J). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 43.9), duodenum adult (RPKM 15.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.2; 3 45.85 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104688322..104693334)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104780952..104786023)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6485 Neighboring gene TAFA chemokine like family member 3 Neighboring gene STARR-seq mESC enhancer starr_08620 Neighboring gene ras homolog family member C Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene STARR-seq mESC enhancer starr_08622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of protein phosphatase 2Czeta by c-Jun NH2-terminal kinase at Ser92 attenuates its phosphatase activity. Awano K, et al. Biochemistry, 2008 Jul 8. PMID 18553930
    2. A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9. Kashiwaba M, et al. FEBS Lett, 2003 Mar 13. PMID 12633878
    3. Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family. Komaki K, et al. Biochim Biophys Acta, 2003 Nov 30. PMID 14654243
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that specific phosphorylation of PP2Czeta at Ser (92) by stress-activated JNK attenuates its phosphatase activity in cells.
      Title: Phosphorylation of protein phosphatase 2Czeta by c-Jun NH2-terminal kinase at Ser92 attenuates its phosphatase activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144853

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1J
    Names
    PP2C-zeta
    protein phosphatase 2C zeta
    NP_082258.2
    XP_006502185.1
    XP_006502186.1
    XP_036019233.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027982.2 → NP_082258.2  protein phosphatase 1J

      See identical proteins and their annotated locations for NP_082258.2

      Status: VALIDATED

      Source sequence(s)
      AC122831, BC117498, BX518856
      Consensus CDS
      CCDS17703.1
      UniProtKB/Swiss-Prot
      Q149T7, Q810X6, Q9D7H6
      Related
      ENSMUSP00000002298.7, ENSMUST00000002298.7
      Conserved Domains (1) summary
      cd00143
      Location:105 → 499
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104688322..104693334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163340.1 → XP_036019233.1  protein phosphatase 1J isoform X2

      Conserved Domains (1) summary
      cd00143
      Location:105 → 440
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. XM_006502122.5 → XP_006502185.1  protein phosphatase 1J isoform X1

      Conserved Domains (1) summary
      cd00143
      Location:105 → 482
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    3. XM_006502123.5 → XP_006502186.1  protein phosphatase 1J isoform X3

      Conserved Domains (1) summary
      cd00143
      Location:56 → 449
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q149T7.1 GenPept UniProtKB/Swiss-Prot:Q149T7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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