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    Rpl29 ribosomal protein L29 [ Mus musculus (house mouse) ]

    Gene ID: 19944, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rpl29provided by MGI
    Official Full Name
    ribosomal protein L29provided by MGI
    Primary source
    MGI:MGI:99687
    See related
    Ensembl:ENSMUSG00000048758 AllianceGenome:MGI:99687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpl43
    Summary
    Enables heparin binding activity. Acts upstream of or within cell population proliferation; cell-substrate adhesion; and translation. Located in cytosolic ribosome and polysomal ribosome. Is extrinsic component of membrane. Is active in synapse. Is expressed in several structures, including gonad; heart; liver; lung; and metanephros. Orthologous to human RPL29 (ribosomal protein L29). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 84.5), liver E14.5 (RPKM 83.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F1; 9 57.49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106306631..106308768)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106428889..106431568)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106274227-106274380 Neighboring gene STARR-positive B cell enhancer ABC_E6800 Neighboring gene dual specificity phosphatase 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106296741-106296928 Neighboring gene predicted gene, 33616 Neighboring gene predicted gene, 46131 Neighboring gene STARR-seq mESC enhancer starr_25150 Neighboring gene STARR-positive B cell enhancer ABC_E11423 Neighboring gene aminoacylase 1 Neighboring gene abhydrolase domain containing 14A Neighboring gene abhydrolase domain containing 14b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effect of HIP/ribosomal protein L29 deficiency on mineral properties of murine bones and teeth. Sloofman LG, et al. Bone, 2010 Jul. PMID 20362701, Free PMC Article
    2. Ribosomal protein L29/HIP deficiency delays osteogenesis and increases fragility of adult bone in mice. Oristian DS, et al. J Orthop Res, 2009 Jan. PMID 18661500, Free PMC Article
    3. HIP/RPL29 down-regulation accompanies terminal chondrocyte differentiation. Miller SA, et al. Differentiation, 2003 Aug. PMID 12919102
    4. Cloning, expression, and chromosome mapping of the murine Hip/Rpl29 gene. Kirn-Safran CB, et al. Genomics, 2000 Sep 1. PMID 10964519
    5. The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29. Ali MI, et al. Sci Rep, 2020 Oct 1. PMID 33004906, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29.
      Title: The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29.
    2. depletion of Rpl29 using RNA interference inhibited VEGF-induced aortic ring sprouting
      Title: Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice.
    3. Consistent with the HIP/RPL29-null bone phenotype, HIP/RPL29-deficient teeth also showed reduced geometric properties accompanied with relative increased mineral densities of both dentin and enamel.
      Title: Effect of HIP/ribosomal protein L29 deficiency on mineral properties of murine bones and teeth.
    4. L29/HIP may have a role in preventing osteogenesis and fragility of adult bone in mice
      Title: Ribosomal protein L29/HIP deficiency delays osteogenesis and increases fragility of adult bone in mice.
    5. RPL29 functions as an important regulator of global growth by modulating the rate of protein synthesis.
      Title: Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29.
    6. analyzed the expression pattern in the mammary gland especially with respect to luminal epithelial cell growth and differentiation during pregnancy and lactation
      Title: Changes in the cytologic distribution of heparin/heparan sulfate interacting protein/ribosomal protein L29 (HIP/RPL29) during in vivo and in vitro mouse mammary epithelial cell expression and differentiation.
    7. Rpl129 down-regulation accompanies terminal chondrocyte differentiation.
      Title: HIP/RPL29 down-regulation accompanies terminal chondrocyte differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107574, MGC107575, MGC107576

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL29
    Names
    60S ribosomal protein L29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324533.2 → NP_001311462.1  large ribosomal subunit protein eL29

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominate transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC151729
      Consensus CDS
      CCDS23476.1
      UniProtKB/Swiss-Prot
      P47915
      UniProtKB/TrEMBL
      A0A1L1SS27, D3Z1N9, Q5M8M8
      Related
      ENSMUSP00000117834.2, ENSMUST00000150576.8
      Conserved Domains (1) summary
      pfam01779
      Location:4 → 42
      Ribosomal_L29e; Ribosomal L29e protein family

    2. NM_001324534.2 → NP_001311463.1  large ribosomal subunit protein eL29

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate segment in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC151729
      Consensus CDS
      CCDS23476.1
      UniProtKB/Swiss-Prot
      P47915
      UniProtKB/TrEMBL
      A0A1L1SS27, D3Z1N9, Q5M8M8
      Related
      ENSMUSP00000149722.2, ENSMUST00000213448.2
      Conserved Domains (1) summary
      pfam01779
      Location:4 → 42
      Ribosomal_L29e; Ribosomal L29e protein family

    3. NM_009082.4 → NP_033108.1  large ribosomal subunit protein eL29

      See identical proteins and their annotated locations for NP_033108.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate segment in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC151729
      Consensus CDS
      CCDS23476.1
      UniProtKB/Swiss-Prot
      P47915
      UniProtKB/TrEMBL
      A0A1L1SS27, D3Z1N9, Q5M8M8
      Related
      ENSMUSP00000080203.6, ENSMUST00000059802.7
      Conserved Domains (1) summary
      pfam01779
      Location:4 → 42
      Ribosomal_L29e; Ribosomal L29e protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106306631..106308768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511660.5 → XP_006511723.1  large ribosomal subunit protein eL29 isoform X1

      See identical proteins and their annotated locations for XP_006511723.1

      UniProtKB/Swiss-Prot
      P47915
      UniProtKB/TrEMBL
      A0A1L1SS27, D3Z1N9, Q5M8M8
      Conserved Domains (1) summary
      pfam01779
      Location:4 → 42
      Ribosomal_L29e; Ribosomal L29e protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47915.2 GenPept UniProtKB/Swiss-Prot:P47915

    Gene LinkOut

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