Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcer1gprovided by MGI
Official Full Name: Fc receptor, IgE, high affinity I, gamma polypeptideprovided by MGI
Primary source: MGI:MGI:95496
See related: Ensembl:ENSMUSG00000058715 AllianceGenome:MGI:95496
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD23; Fce1g; Ly-50; FcR[g]; FcRgamma; FcR-gamma; FcepsilonRI
Summary: Enables IgE receptor activity; IgG binding activity; and identical protein binding activity. Contributes to IgE binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of interleukin-4 production; and serotonin secretion by platelet. Acts upstream of or within several processes, including leukocyte differentiation; positive regulation of cytokine production; and positive regulation of immune response. Located in external side of plasma membrane. Is integral component of plasma membrane. Part of Fc-epsilon receptor I complex. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina. Orthologous to human FCER1G (Fc fragment of IgE receptor Ig). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 104.3), mammary gland adult (RPKM 62.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.23 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171057141..171061918, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171229572..171234349, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
Title: Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through beta-Arrestin and Lack of Correlation with the FcepsilonRI Pathway.
Title: MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway.
Microglial activation and astrogliosis were observed in cortices of Hexb(-/-) mice during the asymptomatic phase, and were inhibited in Hexb(-/-) FcRgamma(-/-) mice.
Title: FcRγ-dependent immune activation initiates astrogliosis during the asymptomatic phase of Sandhoff disease model mice.
deficiency in FcRgamma itself or two receptors to which it couples (dectin-2 and mincle) impacts phagocytosis of six fungal organisms
Title: The pattern recognition receptors dectin-2, mincle, and FcRγ impact the dynamics of phagocytosis of Candida, Saccharomyces, Malassezia, and Mucor species.
FcRgamma plays an important role in regulating CD8+ T-cell functions during chronic LCMV infection.
Title: NK cell-intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection.
this study shows the CD23-induced signaling pathways and their roles in antifungal immunity, specifically for Candida albicans and Aspergillus fumigatus
Title: C-Type Lectin Receptor CD23 Is Required for Host Defense against Candida albicans and Aspergillus fumigatus Infection.
FC epsilon RI receptor role in the mast cell activation and anaphylaxis.Sirt1 negatively regulates Fc epsilon RI-stimulated mast cell activation and anaphylaxis through two mutually regulated pathways involving AMP-activated protein kinase (AMPK) and protein tyrosine phosphatase 1B.
Title: Sirt1 negatively regulates FcεRI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Data (including data from studies conducted with cells from knockout mice) suggest that Cd300e on the surface of monocytes or mast cells recognizes the ligand sphingomyelin and thereby regulates non-classical and intermediate immunologic functions through FcRgamma and DAP12. (Cd300e = CD300 antigen like family member E; FcRgamma = Fc receptor subunit gamma; DAP12 = DNAX-activation protein-12)
Title: The CD300e molecule in mice is an immune-activating receptor.
CD23 deficiency impacts the early cellular event of B-cell receptor (BCR) activation.
Title: CD23 can negatively regulate B-cell receptor signaling.
Dock10 negatively regulates membrane CD23 expression; negative regulation of CD23 expression by Dock10 could play a role in B cell maturation and function
Title: Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in secondary lymphoid tissue.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124203 (e-PCR)
- UniSTS:161025

AI573376 (e-PCR)
- UniSTS:165122

NoName (e-PCR)
- UniSTS:224644

Fcer1g (e-PCR), detects polymorphism
- UniSTS:143082

Ndufs2 (e-PCR), detects polymorphism
- UniSTS:499184

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to IgE binding	IDA Inferred from Direct Assay more info	PubMed
enables IgE binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to IgE binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables IgE receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables IgE receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables IgE receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables IgG binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgG binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Fc receptor mediated stimulatory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Fc receptor mediated stimulatory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Fc-epsilon receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Fc-gamma receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Fc-gamma receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell differentiation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell differentiation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to low-density lipoprotein particle stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-2 production	IPI Inferred from Physical Interaction more info	PubMed
involved_in interleukin-3-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mast cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mast cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mast cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mast cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mast cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of mast cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type I hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type III hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor internalization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of platelet activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin secretion by platelet	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Fc-epsilon receptor I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Fc-epsilon receptor I complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of Fc-gamma receptor III complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: high affinity immunoglobulin epsilon receptor subunit gamma

Names: Fc receptor gamma-chain; fc-epsilon RI-gamma; fceRI gamma; igE Fc receptor subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010185.4 → NP_034315.1 high affinity immunoglobulin epsilon receptor subunit gamma precursor

See identical proteins and their annotated locations for NP_034315.1

Status: VALIDATED

Source sequence(s)

BE634435, BY173505, CK791068

Consensus CDS

CCDS15483.1

UniProtKB/Swiss-Prot

P20491

Related

ENSMUSP00000078875.7, ENSMUST00000079957.12

Conserved Domains (2) summary

smart00077
Location:62 → 82

ITAM; Immunoreceptor tyrosine-based activation motif

pfam11628
Location:21 → 51

TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain