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    Icam1 intercellular adhesion molecule 1 [ Mus musculus (house mouse) ]

    Gene ID: 15894, updated on 23-Jun-2021

    Summary

    Official Symbol
    Icam1provided by MGI
    Official Full Name
    intercellular adhesion molecule 1provided by MGI
    Primary source
    MGI:MGI:96392
    See related
    Ensembl:ENSMUSG00000037405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAL; CD54; Icam; Ly-4; Ly-47; Icam-1; MALA-2
    Summary
    This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1. It participates in the innate immune response. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in lung adult (RPKM 157.0), spleen adult (RPKM 29.7) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Icam1 in Genome Data Viewer
    Location:
    9 A3; 9 7.69 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20927236..20940110)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21015940..21028814)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (20820404..20833241)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene intercellular adhesion molecule 4, Landsteiner-Wiener blood group Neighboring gene microRNA 1900 Neighboring gene intercellular adhesion molecule 5, telencephalin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6195

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within T cell extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in acute inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adhesion of symbiont to host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in establishment of Sertoli cell barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial intestinal barrier ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated virion attachment to host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ruffle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    intercellular adhesion molecule 1
    Names
    myD10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010493.3NP_034623.1  intercellular adhesion molecule 1 precursor

      See identical proteins and their annotated locations for NP_034623.1

      Status: REVIEWED

      Source sequence(s)
      AK151681, AW491621, BY777078
      Consensus CDS
      CCDS22889.1
      UniProtKB/Swiss-Prot
      P13597
      UniProtKB/TrEMBL
      Q3U8M7
      Related
      ENSMUSP00000083587.5, ENSMUST00000086399.6
      Conserved Domains (4) summary
      cd05755
      Location:112206
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      smart00410
      Location:408478
      IG_like; Immunoglobulin like
      pfam03921
      Location:24109
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:313391
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20927236..20940110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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