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    Strada STE20-related kinase adaptor alpha [ Mus musculus (house mouse) ]

    Gene ID: 72149, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Stradaprovided by MGI
    Official Full Name
    STE20-related kinase adaptor alphaprovided by MGI
    Primary source
    MGI:MGI:1919399
    See related
    Ensembl:ENSMUSG00000069631 AllianceGenome:MGI:1919399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610019A05Rik; 6030402H20Rik; E130112C09Rik
    Summary
    Predicted to enable kinase binding activity and protein serine/threonine kinase activator activity. Predicted to contribute to protein serine/threonine kinase activity. Acts upstream of or within activation of protein kinase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular zone; cortical plate; and thymus primordium. Orthologous to human STRADA (STE20 related adaptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 47.7), frontal lobe adult (RPKM 14.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Strada in Genome Data Viewer
    Location:
    11 E1; 11 68.89 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106053739..106084460, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106162974..106193634, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 3 Neighboring gene STARR-seq mESC enhancer starr_30916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106020710-106020950 Neighboring gene predicted gene 10840 Neighboring gene LIM domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E7078 Neighboring gene STARR-positive B cell enhancer ABC_E739 Neighboring gene coiled-coil domain containing 47 Neighboring gene STARR-positive B cell enhancer ABC_E5285 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106078089-106078198 Neighboring gene STARR-positive B cell enhancer ABC_E7080 Neighboring gene DEAD box helicase 42 Neighboring gene STARR-positive B cell enhancer ABC_E5286 Neighboring gene FtsJ RNA 2'-O-methyltransferase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder. Parker WE, et al. Sci Transl Med, 2013 Apr 24. PMID 23616120, Free PMC Article
    2. Multimodal Analysis of STRADA Function in Brain Development. Dang LT, et al. Front Cell Neurosci, 2020. PMID 32457579, Free PMC Article
    3. Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle. Smith CD, et al. J Appl Physiol (1985), 2011 Dec. PMID 21903876, Free PMC Article
    4. STRAD pseudokinases regulate axogenesis and LKB1 stability. Veleva-Rotse BO, et al. Neural Dev, 2014 Mar 4. PMID 24594058, Free PMC Article
    5. Characterization of an alternative splice variant of LKB1. Denison FC, et al. J Biol Chem, 2009 Jan 2. PMID 18854309

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_negative_effect G1 to G0 transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intracellular protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of serine/threonine protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of serine/threonine protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    STE20-related kinase adapter protein alpha
    Names
    STE20-related adapter protein
    STRAD alpha
    protein kinase LYK5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252448.2 → NP_001239377.1  STE20-related kinase adapter protein alpha isoform 1

      See identical proteins and their annotated locations for NP_001239377.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL596331
      Consensus CDS
      CCDS56816.1
      UniProtKB/Swiss-Prot
      Q3UUJ4, Q6VEU7, Q9D0G8
      Related
      ENSMUSP00000007444.8, ENSMUST00000007444.14
      Conserved Domains (1) summary
      cd08227
      Location:70 → 396
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

    2. NM_001252449.2 → NP_001239378.1  STE20-related kinase adapter protein alpha isoform 3

      See identical proteins and their annotated locations for NP_001239378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the 5' coding region and a segment in the 3' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (3) lacks a segment in the N-terminal region and a segment in the C-terminal region, compared to isoform 1.
      Source sequence(s)
      AL596331
      UniProtKB/Swiss-Prot
      Q3UUJ4
      Conserved Domains (2) summary
      smart00220
      Location:32 → 334
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:33 → 347
      PKc_like; Protein Kinases, catalytic domain

    3. NM_028126.4 → NP_082402.1  STE20-related kinase adapter protein alpha isoform 2

      See identical proteins and their annotated locations for NP_082402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the 5' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AL596331
      Consensus CDS
      CCDS25550.1
      UniProtKB/Swiss-Prot
      Q3UUJ4
      Related
      ENSMUSP00000099361.4, ENSMUST00000103072.10
      Conserved Domains (1) summary
      cd08227
      Location:33 → 359
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106053739..106084460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534293.4 → XP_006534356.1  STE20-related kinase adapter protein alpha isoform X2

      Conserved Domains (1) summary
      cd08227
      Location:62 → 388
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

    2. XM_011249270.1 → XP_011247572.1  STE20-related kinase adapter protein alpha isoform X1

      See identical proteins and their annotated locations for XP_011247572.1

      UniProtKB/Swiss-Prot
      Q3UUJ4, Q6VEU7, Q9D0G8
      Related
      ENSMUST00000122989.2
      Conserved Domains (1) summary
      cd08227
      Location:70 → 396
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

    3. XM_006534294.5 → XP_006534357.1  STE20-related kinase adapter protein alpha isoform X3

      Conserved Domains (1) summary
      cd08227
      Location:41 → 367
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

    4. XM_006534297.5 → XP_006534360.1  STE20-related kinase adapter protein alpha isoform X5

      See identical proteins and their annotated locations for XP_006534360.1

      Conserved Domains (1) summary
      cd08227
      Location:13 → 339
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

    5. XM_006534296.5 → XP_006534359.1  STE20-related kinase adapter protein alpha isoform X5

      See identical proteins and their annotated locations for XP_006534359.1

      Conserved Domains (1) summary
      cd08227
      Location:13 → 339
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

    6. XM_006534295.3 → XP_006534358.1  STE20-related kinase adapter protein alpha isoform X4

      See identical proteins and their annotated locations for XP_006534358.1

      UniProtKB/Swiss-Prot
      Q3UUJ4
      Conserved Domains (1) summary
      cd08227
      Location:33 → 359
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

    7. XM_030246360.2 → XP_030102220.1  STE20-related kinase adapter protein alpha isoform X3

      Conserved Domains (1) summary
      cd08227
      Location:41 → 367
      PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UUJ4.1 GenPept UniProtKB/Swiss-Prot:Q3UUJ4

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