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    Myo7b myosin VIIB [ Mus musculus (house mouse) ]

    Gene ID: 17922, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Myo7bprovided by MGI
    Official Full Name
    myosin VIIBprovided by MGI
    Primary source
    MGI:MGI:107709
    See related
    Ensembl:ENSMUSG00000024388 AllianceGenome:MGI:107709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in several processes, including brush border assembly; sensory perception of sound; and vesicle transport along actin filament. Predicted to act upstream of or within cell differentiation. Located in apical cytoplasm; brush border; and microvillus. Is expressed in genitourinary system and gut. Orthologous to human MYO7B (myosin VIIB). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in small intestine adult (RPKM 52.2), duodenum adult (RPKM 47.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myo7b in Genome Data Viewer
    Location:
    18 B1; 18 17.89 cM
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32092287..32169984, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (31959234..32036931, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44150 Neighboring gene LIM and senescent cell antigen like domains 2 Neighboring gene predicted gene, 46619 Neighboring gene G protein-coupled receptor 17 Neighboring gene STARR-seq mESC enhancer starr_44152 Neighboring gene predicted gene 16344 Neighboring gene STARR-seq mESC enhancer starr_44153 Neighboring gene predicted gene, 35010 Neighboring gene IWS1, SUPT6 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Vertebrate myosin VIIb is a high duty ratio motor adapted for generating and maintaining tension. Henn A, et al. J Biol Chem, 2005 Nov 25. PMID 16186105
    2. The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex. Choi MS, et al. J Biol Chem, 2020 Jul 10. PMID 32209652, Free PMC Article
    3. Myosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia. Chen ZY, et al. Genomics, 2001 Mar 15. PMID 11401444
    4. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Crawley SW, et al. Cell, 2014 Apr 10. PMID 24725409, Free PMC Article
    5. Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea. Durán Alonso MB, et al. Front Cell Dev Biol, 2021. PMID 34124068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloned, expressed and purified the catalytic motor domain, and characterized its actin-activated ATPase cycle
      Title: Vertebrate myosin VIIb is a high duty ratio motor adapted for generating and maintaining tension.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brush border assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-VIIb
    Names
    myosin-VIIb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032394.3 → NP_115770.2  unconventional myosin-VIIb

      See identical proteins and their annotated locations for NP_115770.2

      Status: VALIDATED

      Source sequence(s)
      AC131761, AK220152, BC138341
      Consensus CDS
      CCDS50244.1
      UniProtKB/Swiss-Prot
      B9EHR5, Q571N7, Q8R0U3, Q99MZ6
      Related
      ENSMUSP00000118046.2, ENSMUST00000134663.2
      Conserved Domains (9) summary
      smart00015
      Location:785 → 807
      IQ; Calmodulin-binding motif
      smart00139
      Location:1641 → 1788
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1797 → 2009
      B41; Band 4.1 homologues
      cd13198
      Location:1403 → 1499
      FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
      cd13199
      Location:2005 → 2100
      FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
      cd01381
      Location:79 → 748
      MYSc_Myo7; class VII myosin, motor domain
      cd17092
      Location:1193 → 1291
      FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins
      cd17093
      Location:1795 → 1892
      FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins
      cl17036
      Location:1500 → 1560
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      32092287..32169984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MZ6.3 GenPept UniProtKB/Swiss-Prot:Q99MZ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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