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    Fbxl13 F-box and leucine-rich repeat protein 13 [ Mus musculus (house mouse) ]

    Gene ID: 320118, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fbxl13provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 13provided by MGI
    Primary source
    MGI:MGI:2443416
    See related
    Ensembl:ENSMUSG00000048520 AllianceGenome:MGI:2443416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921539K22Rik
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; lung; and reproductive system. Orthologous to human FBXL13 (F-box and leucine rich repeat protein 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 14.6) and ovary adult (RPKM 0.6) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 A3; 5 9.83 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21688845..21850696, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21483847..21645698, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene gamma-secretase activating protein Neighboring gene STARR-positive B cell enhancer ABC_E6308 Neighboring gene coiled-coil domain containing 146 Neighboring gene VISTA enhancer mm186 Neighboring gene STARR-positive B cell enhancer ABC_E6309 Neighboring gene predicted gene, 50626 Neighboring gene STARR-positive B cell enhancer ABC_E6310 Neighboring gene STARR-seq mESC enhancer starr_12565 Neighboring gene STARR-positive B cell enhancer ABC_E3562 Neighboring gene STARR-positive B cell enhancer ABC_E152 Neighboring gene fibrinogen-like protein 2 Neighboring gene family with sequence similarity 185, member A Neighboring gene STARR-seq mESC enhancer starr_12566 Neighboring gene STARR-seq mESC enhancer starr_12567 Neighboring gene leucine rich repeat containing 17 Neighboring gene STARR-seq mESC enhancer starr_12568 Neighboring gene STARR-seq mESC enhancer starr_12569 Neighboring gene predicted gene 6543 Neighboring gene STARR-positive B cell enhancer ABC_E11283 Neighboring gene protein archease pseudogene Neighboring gene STARR-seq mESC enhancer starr_12572 Neighboring gene armadillo repeat containing 10 Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene microRNA 12197

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. Morohoshi A, et al. PLoS Genet, 2020 Jan. PMID 31961863, Free PMC Article
    2. TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Castaneda JM, et al. Proc Natl Acad Sci U S A, 2017 Jul 3. PMID 28630322, Free PMC Article
    3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of Fbxl13 has no observable effect on sperm function.
      Title: Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    F-box and leucine-rich repeat protein 13
    Names
    F-box/LRR-repeat protein 13
    dynein regulatory complex subunit 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199632.1 → NP_001186561.1  F-box and leucine-rich repeat protein 13 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform a).
      Source sequence(s)
      BB614373, BC145291, CO797010
      UniProtKB/TrEMBL
      B7ZNK1
      Conserved Domains (5) summary
      cd09293
      Location:536 → 752
      AMN1; Antagonist of mitotic exit network protein 1
      sd00033
      Location:486 → 523
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:537 → 564
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:240 → 286
      F-box-like; F-box-like
      cl06673
      Location:54 → 92
      Extradiol_Dioxygenase_3A_like; Subunit A of Class III extradiol dioxygenases

    2. NM_177076.4 → NP_796050.2  F-box and leucine-rich repeat protein 13 isoform b

      See identical proteins and their annotated locations for NP_796050.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.
      Source sequence(s)
      BB614373, BC145292, CO797010
      Consensus CDS
      CCDS51429.1
      UniProtKB/Swiss-Prot
      Q8CDE9, Q8CDU4
      UniProtKB/TrEMBL
      B7ZNK2
      Related
      ENSMUSP00000052716.5, ENSMUST00000051358.11
      Conserved Domains (5) summary
      cd09293
      Location:503 → 719
      AMN1; Antagonist of mitotic exit network protein 1
      sd00033
      Location:453 → 470
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:504 → 531
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:240 → 286
      F-box-like; F-box-like
      cl06673
      Location:54 → 92
      Extradiol_Dioxygenase_3A_like; Subunit A of Class III extradiol dioxygenases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      21688845..21850696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535728.3 → XP_006535791.1  F-box and leucine-rich repeat protein 13 isoform X3

      UniProtKB/TrEMBL
      B7ZNK1
      Conserved Domains (4) summary
      cd09293
      Location:536 → 752
      AMN1; Antagonist of mitotic exit network protein 1
      sd00033
      Location:486 → 523
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:537 → 564
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:240 → 284
      F-box-like

    2. XM_011249772.2 → XP_011248074.1  F-box and leucine-rich repeat protein 13 isoform X5

      Conserved Domains (2) summary
      cd09293
      Location:91 → 223
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:54 → 79
      LRR_AMN1; leucine-rich repeat [structural motif]

    3. XM_011249771.4 → XP_011248073.1  F-box and leucine-rich repeat protein 13 isoform X4

      Conserved Domains (3) summary
      cd09293
      Location:211 → 380
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:185 → 211
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:145 → 189
      F-box-like

    4. XM_011249770.4 → XP_011248072.1  F-box and leucine-rich repeat protein 13 isoform X2

      Conserved Domains (3) summary
      cd09293
      Location:306 → 572
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:331 → 356
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:240 → 284
      F-box-like

    5. XM_011249769.3 → XP_011248071.1  F-box and leucine-rich repeat protein 13 isoform X1

      Conserved Domains (3) summary
      cd09293
      Location:306 → 475
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:280 → 306
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:240 → 284
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CDU4.2 GenPept UniProtKB/Swiss-Prot:Q8CDU4

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