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    Thsd1 thrombospondin, type I, domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 56229, updated on 16-Oct-2021

    Summary

    Official Symbol
    Thsd1provided by MGI
    Official Full Name
    thrombospondin, type I, domain 1provided by MGI
    Primary source
    MGI:MGI:1929096
    See related
    Ensembl:ENSMUSG00000031480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmtsp; 4833423O18Rik
    Expression
    Broad expression in lung adult (RPKM 7.1), bladder adult (RPKM 3.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Thsd1 in Genome Data Viewer
    Location:
    8; 8 A2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22711623..22752973)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22220938..22262957)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23348972..23370361)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29878 Neighboring gene vacuolar protein sorting 36 Neighboring gene ribosomal protein L30, pseudogene 2 Neighboring gene transmembrane phosphatase with tensin homology Neighboring gene predicted gene, 46035 Neighboring gene solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    thrombospondin type-1 domain-containing protein 1
    Names
    transmembrane molecule with thrombospondin module

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205253.1NP_001192182.1  thrombospondin type-1 domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001192182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus and lacks a predicted signal peptide, compared to isoform 1.
      Source sequence(s)
      AC121933, AK052555, BY075510
      Consensus CDS
      CCDS85512.1
      UniProtKB/TrEMBL
      A0A1B0GT60
      Related
      ENSMUSP00000148214.2, ENSMUST00000162447.2
      Conserved Domains (1) summary
      smart00209
      Location:281330
      TSP1; Thrombospondin type 1 repeats
    2. NM_001293688.1NP_001280617.1  thrombospondin type-1 domain-containing protein 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001280617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC117665, AC121933, BC051957, BY075510
      Consensus CDS
      CCDS80862.1
      UniProtKB/TrEMBL
      G3XA27
      Related
      ENSMUSP00000125118.2, ENSMUST00000160585.2
    3. NM_019576.2NP_062522.1  thrombospondin type-1 domain-containing protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_062522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC117665, AC121933
      Consensus CDS
      CCDS22172.1
      UniProtKB/Swiss-Prot
      Q9JM61
      UniProtKB/TrEMBL
      A0A0R4J0U4
      Related
      ENSMUSP00000067701.4, ENSMUST00000069828.10
      Conserved Domains (2) summary
      smart00209
      Location:342391
      TSP1; Thrombospondin type 1 repeats
      PTZ00441
      Location:289406
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22711623..22752973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509174.5XP_006509237.1  thrombospondin type-1 domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006509237.1

      UniProtKB/Swiss-Prot
      Q9JM61
      UniProtKB/TrEMBL
      A0A0R4J0U4
      Conserved Domains (2) summary
      smart00209
      Location:342391
      TSP1; Thrombospondin type 1 repeats
      PTZ00441
      Location:289406
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    2. XM_030243688.2XP_030099548.1  thrombospondin type-1 domain-containing protein 1 isoform X2

      Conserved Domains (2) summary
      smart00209
      Location:342391
      TSP1; Thrombospondin type 1 repeats
      PTZ00441
      Location:289406
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    3. XM_030243689.2XP_030099549.1  thrombospondin type-1 domain-containing protein 1 isoform X3

    4. XM_006509177.5XP_006509240.1  thrombospondin type-1 domain-containing protein 1 isoform X4

    5. XM_030243690.2XP_030099550.1  thrombospondin type-1 domain-containing protein 1 isoform X3

    6. XM_006509173.5XP_006509236.1  thrombospondin type-1 domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006509236.1

      UniProtKB/Swiss-Prot
      Q9JM61
      UniProtKB/TrEMBL
      A0A0R4J0U4
      Conserved Domains (2) summary
      smart00209
      Location:342391
      TSP1; Thrombospondin type 1 repeats
      PTZ00441
      Location:289406
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
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