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    Wtap WT1 associating protein [ Mus musculus (house mouse) ]

    Gene ID: 60532, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Wtapprovided by MGI
    Official Full Name
    WT1 associating proteinprovided by MGI
    Primary source
    MGI:MGI:1926395
    See related
    Ensembl:ENSMUSG00000060475 AllianceGenome:MGI:1926395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810408K05Rik; 9430038B09Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in mRNA methylation and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Located in cytoplasm and nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in several structures, including early conceptus; embryo mesoderm; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human WTAP (WT1 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.9), CNS E18 (RPKM 10.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A1; 17 8.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13185686..13211430, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12966799..12992543, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene t-complex protein 1, pseudogene 2 Neighboring gene acetyl-Coenzyme A acetyltransferase 2 Neighboring gene predicted gene 15946 Neighboring gene STARR-seq mESC enhancer starr_41863 Neighboring gene STARR-seq mESC enhancer starr_41864 Neighboring gene STARR-positive B cell enhancer ABC_E7488 Neighboring gene STARR-positive B cell enhancer ABC_E10934 Neighboring gene STARR-positive B cell enhancer ABC_E10935 Neighboring gene superoxide dismutase 2, mitochondrial Neighboring gene predicted gene, 36117

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization. Bai Y, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Aug. PMID 37019244
    2. WTAP mediates FOXP3 mRNA stability to promote SMARCE1 expression and augment glycolysis in colon adenocarcinoma. Zhang Y, et al. Mamm Genome, 2022 Dec. PMID 36173464
    3. Loss of Wtap results in cerebellar ataxia and degeneration of Purkinje cells. Yang Y, et al. J Genet Genomics, 2022 Sep. PMID 35304325
    4. WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche. Jia GX, et al. Stem Cell Reports, 2020 Oct 13. PMID 33053361, Free PMC Article
    5. WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner. Pan Q, et al. Environ Toxicol, 2023 Jun. PMID 36988233

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes.
      Title: Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes.
    2. WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo.
      Title: WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo.
    3. WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.
      Title: WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization.
    4. Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice.
      Title: Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice.
    5. WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner.
      Title: WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner.
    6. WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis.
      Title: WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis.
    7. WTAP-mediated m[6]A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis.
      Title: WTAP-mediated m(6)A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis.
    8. N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis.
      Title: N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis.
    9. WTAP mediates FOXP3 mRNA stability to promote SMARCE1 expression and augment glycolysis in colon adenocarcinoma.
      Title: WTAP mediates FOXP3 mRNA stability to promote SMARCE1 expression and augment glycolysis in colon adenocarcinoma.
    10. Loss of Wtap results in cerebellar ataxia and degeneration of Purkinje cells.
      Title: Loss of Wtap results in cerebellar ataxia and degeneration of Purkinje cells.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pre-mRNA-splicing regulator WTAP
    Names
    WT1-associated protein
    Wilms tumour 1-associating protein
    Wilms' tumour 1-associating protein
    female-lethal(2)D homolog
    wilms tumor 1-associating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113532.1 → NP_001107004.1  pre-mRNA-splicing regulator WTAP isoform b

      See identical proteins and their annotated locations for NP_001107004.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a different 3' UTR, compared to variant 1. It encodes isoform b which is C-terminal truncated, compared to isoform a. Variants 2 and 3 encode the same isoform b.
      Source sequence(s)
      AK031965, AK041341, BC093504, BY016042
      Consensus CDS
      CCDS49949.1
      UniProtKB/TrEMBL
      F7CCI4
      Related
      ENSMUSP00000123961.2, ENSMUST00000159986.8
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 150
      Wtap; WTAP/Mum2p family

    2. NM_001113533.1 → NP_001107005.1  pre-mRNA-splicing regulator WTAP isoform a

      See identical proteins and their annotated locations for NP_001107005.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL589878
      Consensus CDS
      CCDS49950.1
      UniProtKB/Swiss-Prot
      Q3U120, Q566J5, Q9ER69
      UniProtKB/TrEMBL
      E0CYH0
      Related
      ENSMUSP00000007007.8, ENSMUST00000007007.14
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 222
      Wtap; WTAP/Mum2p family

    3. NM_001379058.1 → NP_001365987.1  pre-mRNA-splicing regulator WTAP isoform a

      Status: VALIDATED

      Source sequence(s)
      AL589878
      UniProtKB/Swiss-Prot
      Q3U120, Q566J5, Q9ER69
      UniProtKB/TrEMBL
      E0CYH0
      Related
      ENSMUSP00000124205.2, ENSMUST00000159551.8
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 222
      Wtap; WTAP/Mum2p family

    4. NM_175394.2 → NP_780603.1  pre-mRNA-splicing regulator WTAP isoform b

      See identical proteins and their annotated locations for NP_780603.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 5' UTR exon and lacks two exons, and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a different 3' UTR, compared to variant 1. It encodes isoform b which is C-terminal truncated, compared to isoform a. Variants 2 and 3 encode the same isoform b.
      Source sequence(s)
      AK031965, AK041341, AK076111
      Consensus CDS
      CCDS49949.1
      UniProtKB/TrEMBL
      F7CCI4
      Related
      ENSMUSP00000124138.2, ENSMUST00000160781.8
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 150
      Wtap; WTAP/Mum2p family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      13185686..13211430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER69.3 GenPept UniProtKB/Swiss-Prot:Q9ER69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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