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    Ptgr1 prostaglandin reductase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67103, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ptgr1provided by MGI
    Official Full Name
    prostaglandin reductase 1provided by MGI
    Primary source
    MGI:MGI:1914353
    See related
    Ensembl:ENSMUSG00000028378
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zadh; DIG-1; Ltb4d; Zadh3; Ltb4dh; 2510002C21Rik
    Expression
    Biased expression in bladder adult (RPKM 46.6), stomach adult (RPKM 29.1) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Ptgr1 in Genome Data Viewer
    Location:
    4; 4 B3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (58965590..58987131, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (58965590..58987131, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (58978462..58999950, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Ecm29 proteasome adaptor and scaffold Neighboring gene zinc finger with KRAB and SCAN domains 16 Neighboring gene DnaJ heat shock protein family (Hsp40) member C25 Neighboring gene guanine nucleotide binding protein (G protein), gamma 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 13-prostaglandin reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 15-oxoprostaglandin 13-oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 2-alkenal reductase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 2-alkenal reductase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    prostaglandin reductase 1
    Names
    15-oxoprostaglandin 13-reductase
    D3T-inducible gene 1 protein
    NAD(P)H-dependent alkenal/one oxidoreductase
    NADP-dependent leukotriene B4 12-hydroxydehydrogenase
    PRG-1
    dithiolethione-inducible gene 1 protein
    leukotriene B4 12-hydroxydehydrogenase
    NP_080244.1
    XP_011248390.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025968.3NP_080244.1  prostaglandin reductase 1

      See identical proteins and their annotated locations for NP_080244.1

      Status: PROVISIONAL

      Source sequence(s)
      AK035425
      Consensus CDS
      CCDS18215.1
      UniProtKB/Swiss-Prot
      Q91YR9
      Related
      ENSMUSP00000030069.7, ENSMUST00000030069.7
      Conserved Domains (2) summary
      TIGR02825
      Location:4328
      B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
      cd08294
      Location:2329
      leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      58965590..58987131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250088.1XP_011248390.1  prostaglandin reductase 1 isoform X1

      Conserved Domains (1) summary
      TIGR02825
      Location:4263
      B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
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