U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ascc3 activating signal cointegrator 1 complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 77987, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ascc3provided by MGI
    Official Full Name
    activating signal cointegrator 1 complex subunit 3provided by MGI
    Primary source
    MGI:MGI:1925237
    See related
    Ensembl:ENSMUSG00000038774 AllianceGenome:MGI:1925237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNAH; Helic1; ASC1p200; D630041L21; B630009I04Rik; D430001L07Rik
    Summary
    Predicted to enable 3'-5' DNA helicase activity. Predicted to be involved in several processes, including DNA dealkylation involved in DNA repair; DNA duplex unwinding; and cellular protein metabolic process. Predicted to act upstream of or within DNA repair. Predicted to be located in cytosol. Predicted to be part of activating signal cointegrator 1 complex. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.7), liver E14 (RPKM 3.6) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    10 B3; 10 24.87 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (50468756..50727300)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (50592663..50851202)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57555 Neighboring gene predicted gene, 46199 Neighboring gene STARR-seq mESC enhancer starr_26642 Neighboring gene STARR-positive B cell enhancer ABC_E8333 Neighboring gene STARR-seq mESC enhancer starr_26643 Neighboring gene STARR-positive B cell enhancer mm9_chr10:50482908-50483208 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26645 Neighboring gene RIKEN cDNA A230054N11 gene Neighboring gene single-minded family bHLH transcription factor 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. PEG3 control on the mammalian MSL complex. Ye A, et al. PLoS One, 2017. PMID 28609438, Free PMC Article
    2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA repair complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of activating signal cointegrator 1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    activating signal cointegrator 1 complex subunit 3
    Names
    helicase, ATP binding 1
    NP_932124.2
    XP_030101248.1
    XP_030101249.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198007.2 → NP_932124.2  activating signal cointegrator 1 complex subunit 3

      See identical proteins and their annotated locations for NP_932124.2

      Status: VALIDATED

      Source sequence(s)
      AC137877, AC153529, AC159114
      Consensus CDS
      CCDS48555.1
      UniProtKB/Swiss-Prot
      E9PZJ8, Q6PB36, Q8C1G1, Q8C707, Q8K292
      Related
      ENSMUSP00000036726.9, ENSMUST00000035606.10
      Conserved Domains (5) summary
      smart00490
      Location:1615 → 1694
      HELICc; helicase superfamily c-terminal domain
      smart00611
      Location:1810 → 2179
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:461 → 1240
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      pfam00270
      Location:1329 → 1500
      DEAD; DEAD/DEAH box helicase
      pfam02889
      Location:979 → 1287
      Sec63; Sec63 Brl domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      50468756..50727300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245388.2 → XP_030101248.1  activating signal cointegrator 1 complex subunit 3 isoform X1

      Conserved Domains (3) summary
      COG1204
      Location:363 → 1142
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:1229 → 1417
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3
      pfam18149
      Location:152 → 193
      Helicase_PWI; N-terminal helicase PWI domain

    2. XM_030245389.2 → XP_030101249.1  activating signal cointegrator 1 complex subunit 3 isoform X2

      Conserved Domains (2) summary
      COG1204
      Location:125 → 904
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:991 → 1179
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PZJ8.1 GenPept UniProtKB/Swiss-Prot:E9PZJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous