Pla2r1 phospholipase A2 receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2r1provided by MGI
Official Full Name: phospholipase A2 receptor 1provided by MGI
Primary source: MGI:MGI:102468
See related: Ensembl:ENSMUSG00000054580 AllianceGenome:MGI:102468
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pla2r; Pla2-r; Pla2g1br
Summary: Enables phospholipase binding activity. Involved in negative regulation of phospholipase A2 activity; receptor-mediated endocytosis; and regulation of arachidonic acid secretion. Located in extracellular region. Is expressed in central nervous system and sensory organ. Orthologous to human PLA2R1 (phospholipase A2 receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 10.8), lung adult (RPKM 2.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 34.65 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (60247887..60383669, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (60417543..60553326, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western diets.
Title: Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western diets.
PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging.
Title: PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging.
Deficiency of Phospholipase A2 Receptor Exacerbates Autoimmune Myocarditis in Mice.
Title: Deficiency of Phospholipase A(2) Receptor Exacerbates Autoimmune Myocarditis in Mice.
PLA2R1 mediates key premature aging phenotypes through a p53/FDPS pathway and might be a new therapeutic target.
Title: Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes.
PLA2R1 is increased in the airway epithelium in asthma, and serves as a regulator of airway hyperresponsiveness, airway permeability, antigen sensitization, and airway inflammation.
Title: Identification of Epithelial Phospholipase A(2) Receptor 1 as a Potential Target in Asthma.
Study showed that CTLD1-2 as well as the FNII domain of PLA2R were responsible for binding to collagen I and collagen-dependent migration in both mouse and human PLA2R.
Title: C-type lectin-like domain and fibronectin-like type II domain of phospholipase A(2) receptor 1 modulate binding and migratory responses to collagen.
PLA2R might play a pathogenic role in myocardial infarction of PLA2R-deficient mice, through impaired healing of the infarcted region.
Title: Lack of phospholipase A2 receptor increases susceptibility to cardiac rupture after myocardial infarction.
PLA2R deficiency increased sPLA2-IB and -X levels in the lung through their impaired clearance from the lung, leading to exaggeration of lung inflammation induced by OVA treatment in a murine model.
Title: Deficiency of phospholipase A2 receptor exacerbates ovalbumin-induced lung inflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D30779 (e-PCR)
- UniSTS:163284

AU015584 (e-PCR)
- UniSTS:207334

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of arachidonic acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
involved_in oxidative stress-induced premature senescence	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of arachidonic acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in replicative senescence	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: secretory phospholipase A2 receptor

Names: 180 kDa secretory phospholipase A2 receptor; M-type receptor; PLA2-I receptor; phospholipase A2, group IB, pancreas, receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008867.2 → NP_032893.1 secretory phospholipase A2 receptor precursor

See identical proteins and their annotated locations for NP_032893.1

Status: VALIDATED

Source sequence(s)

AK036808, BC141356, BX679662, BY772059

Consensus CDS

CCDS16059.1

UniProtKB/Swiss-Prot

A2AS64, B9EJ68, Q62028, Q80ZL5

Related

ENSMUSP00000108144.4, ENSMUST00000112525.5

Conserved Domains (5) summary

cd00037
Location:245 → 358

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00034
Location:380 → 504

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:47 → 154

RICIN; Ricin-type beta-trefoil

cd00062
Location:175 → 222

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00161
Location:55 → 123

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

60247887..60383669 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498928.5 → XP_006498991.1 secretory phospholipase A2 receptor isoform X1

Conserved Domains (3) summary

cd00037
Location:153 → 266

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00034
Location:288 → 412

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

cd00062
Location:83 → 130

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...