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    Mphosph6 M phase phosphoprotein 6 [ Mus musculus (house mouse) ]

    Gene ID: 68533, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mphosph6provided by MGI
    Official Full Name
    M phase phosphoprotein 6provided by MGI
    Primary source
    MGI:MGI:1915783
    See related
    Ensembl:ENSMUSG00000031843 AllianceGenome:MGI:1915783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110001M01Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA. Predicted to act upstream of or within rRNA processing. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of nuclear exosome (RNase complex). Is expressed in left lung; orbito-sphenoid; right lung; and testis. Orthologous to human MPHOSPH6 (M-phase phosphoprotein 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 17.2), CNS E11.5 (RPKM 15.7) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E1; 8 65.09 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (118518376..118528713, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (117791637..117801974, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 2 Neighboring gene predicted gene, 31774 Neighboring gene STARR-positive B cell enhancer mm9_chr8:120303396-120303696 Neighboring gene STARR-positive B cell enhancer ABC_E9744 Neighboring gene predicted gene, 39261 Neighboring gene STARR-positive B cell enhancer ABC_E1377 Neighboring gene predicted gene, 39262 Neighboring gene predicted gene, 25200

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The 5.8S pre-rRNA maturation factor, M-phase phosphoprotein 6, is a female fertility factor required for oocyte quality and meiosis. Peng RR, et al. Cell Prolif, 2020 Mar. PMID 32003502, Free PMC Article
    2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5.8S rRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    M-phase phosphoprotein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357232.1 → NP_001344161.1  M-phase phosphoprotein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122036
      Conserved Domains (1) summary
      pfam10175
      Location:1 → 118
      MPP6; M-phase phosphoprotein 6

    2. NM_001357233.1 → NP_001344162.1  M-phase phosphoprotein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122036
      Conserved Domains (1) summary
      pfam10175
      Location:8 → 134
      MPP6; M-phase phosphoprotein 6

    3. NM_026758.4 → NP_081034.1  M-phase phosphoprotein 6 isoform 1

      See identical proteins and their annotated locations for NP_081034.1

      Status: VALIDATED

      Source sequence(s)
      AC122036, AK003245, AU022509, CJ084018, DV660881
      Consensus CDS
      CCDS22702.1
      UniProtKB/Swiss-Prot
      Q9D1Q1
      Related
      ENSMUSP00000034303.2, ENSMUST00000034303.3
      Conserved Domains (1) summary
      pfam10175
      Location:8 → 136
      MPP6; M-phase phosphoprotein 6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      118518376..118528713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1Q1.1 GenPept UniProtKB/Swiss-Prot:Q9D1Q1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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