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    Car2 carbonic anhydrase 2 [ Mus musculus (house mouse) ]

    Gene ID: 12349, updated on 26-Jun-2021

    Summary

    Official Symbol
    Car2provided by MGI
    Official Full Name
    carbonic anhydrase 2provided by MGI
    Primary source
    MGI:MGI:88269
    See related
    Ensembl:ENSMUSG00000027562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C; Ca2; Car; CAII; Ltw-; Lvtw; Car-2; Ltw-5; Lvtw-5; AI131712
    Expression
    Biased expression in liver E14 (RPKM 556.3), liver E14.5 (RPKM 538.2) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Car2 in Genome Data Viewer
    Location:
    3 A1; 3 3.23 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (14951329..14965830)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (14886269..14900770)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (14886426..14900770)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 1 Neighboring gene cytochrome c oxidase, subunit VIc pseudogene Neighboring gene predicted gene, 41999 Neighboring gene carbonic anhydrase 3 Neighboring gene RIKEN cDNA A930001A20 gene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 42000

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Chemically induced (ENU) (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arylesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables carbonate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carbonate dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables carbonate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydro-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carbon dioxide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within carbon dioxide transport IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within carbon dioxide transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cellular pH reduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular pH reduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dipeptide transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of chloride transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of intracellular pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of pH IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    carbonic anhydrase 2
    Names
    carbonate dehydratase II
    carbonic anhydrase II
    NP_001344263.1
    NP_033931.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357334.1NP_001344263.1  carbonic anhydrase 2

      Status: VALIDATED

      Source sequence(s)
      AC098725, AC123747, CD774528, CK618053
      Consensus CDS
      CCDS17251.1
      Conserved Domains (1) summary
      cl00012
      Location:1259
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    2. NM_009801.5NP_033931.4  carbonic anhydrase 2

      See identical proteins and their annotated locations for NP_033931.4

      Status: VALIDATED

      Source sequence(s)
      AC123747, AK002333, CD774528
      Consensus CDS
      CCDS17251.1
      UniProtKB/Swiss-Prot
      P00920
      Related
      ENSMUSP00000029078.8, ENSMUST00000029078.9
      Conserved Domains (1) summary
      cl00012
      Location:1259
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      14951329..14965830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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