Nup153 nucleoporin 153 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nup153provided by MGI
Official Full Name: nucleoporin 153provided by MGI
Primary source: MGI:MGI:2385621
See related: Ensembl:ENSMUSG00000021374 AllianceGenome:MGI:2385621
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B130015D15Rik
Summary: Predicted to enable several functions, including nuclear localization sequence binding activity; small GTPase binding activity; and zinc ion binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including negative regulation of RNA export from nucleus; nuclear pore complex assembly; and nucleocytoplasmic transport. Predicted to be located in annulate lamellae; cytosol; and nucleus. Predicted to be part of nuclear pore nuclear basket. Is expressed in embryo; lung; neural tube; and retina. Orthologous to human NUP153 (nucleoporin 153). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 42.1), thymus adult (RPKM 15.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 24.3 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (46833369..46890682, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (46679902..46727849, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding.
Title: Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding.
These data uncover a novel role for Nup153 in neural stem cells from animal model of Alzheimer's disease.
Title: Altered Nup153 Expression Impairs the Function of Cultured Hippocampal Neural Stem Cells Isolated from a Mouse Model of Alzheimer's Disease.
Nucleoporins 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells.
Title: Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells.
Nup153 and Sox2 bind and co-regulate hundreds of genes.
Title: Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.
Nup50 dynamics are independent of importin alpha, Nup153, and Nup98, even though the latter two proteins also exhibit transcription-dependent mobility.
Title: Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics.
results demonstrate a chromatin-associated role of Nup153 in maintaining stem cell pluripotency by functioning in mammalian epigenetic gene silencing
Title: The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126422 (e-PCR)
- UniSTS:163130

C88147 (e-PCR)
- UniSTS:165868

RH141746 (e-PCR)
- UniSTS:223739

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in nuclear pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in annulate lamellae	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inclusion body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear periphery	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed
part_of nuclear pore nuclear basket	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasmic side of nuclear pore	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear pore complex protein Nup153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175749.2 → NP_786925.2 nuclear pore complex protein Nup153

Status: VALIDATED

Source sequence(s)

AK031006, AK044947, AK086847, BM950067, CA326562, CF897724, CF898039, CK638380

Consensus CDS

CCDS26486.1

UniProtKB/TrEMBL

E9Q3G8, Q80WR0

Related

ENSMUSP00000021803.9, ENSMUST00000021803.10

Conserved Domains (4) summary

sd00025
Location:658 → 677

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:718 → 746

zf-RanBP; Zn-finger in Ran binding protein and others

pfam08604
Location:114 → 625

Nup153; Nucleoporin Nup153-like

pfam10599
Location:1372 → 1462

Nup_retrotrp_bd; Retro-transposon transporting motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

46833369..46890682 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157992.1 → XP_036013885.1 nuclear pore complex protein Nup153 isoform X1

UniProtKB/TrEMBL

Q80WR0

Conserved Domains (4) summary

sd00025
Location:367 → 386

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam10599
Location:1081 → 1171

Nup_retrotrp_bd; Retro-transposon transporting motif

pfam00641
Location:427 → 455

zf-RanBP; Zn-finger in Ran binding protein and others

pfam08604
Location:1 → 326

Nup153; Nucleoporin Nup153-like
XM_036157993.1 → XP_036013886.1 nuclear pore complex protein Nup153 isoform X2

UniProtKB/TrEMBL

Q80UN3

Conserved Domains (4) summary

sd00025
Location:147 → 166

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam10599
Location:861 → 951

Nup_retrotrp_bd; Retro-transposon transporting motif

pfam00641
Location:207 → 235

zf-RanBP; Zn-finger in Ran binding protein and others

pfam08604
Location:1 → 106

Nup153; Nucleoporin Nup153-like