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    Prodh2 proline dehydrogenase (oxidase) 2 [ Mus musculus (house mouse) ]

    Gene ID: 56189, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Prodh2provided by MGI
    Official Full Name
    proline dehydrogenase (oxidase) 2provided by MGI
    Primary source
    MGI:MGI:1929093
    See related
    Ensembl:ENSMUSG00000036892 AllianceGenome:MGI:1929093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    POX1; HYPDH; MmPOX; MmPOX1; 2510028N04Rik; 2510038B11Rik
    Summary
    Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to act upstream of or within proline metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; renal cortex; and sensory organ. Orthologous to human PRODH2 (proline dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 113.0), liver E18 (RPKM 66.3) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B1; 7 18.36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30193011..30212830)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30493586..30513402)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nephrosis 1, nephrin Neighboring gene nephrosis 1 homolog, nephrin, opposite strand Neighboring gene ribosomal protein S12, pseudogene 4 Neighboring gene Rho GTPase activating protein 33, opposite strand Neighboring gene Rho GTPase activating protein 33 Neighboring gene STARR-positive B cell enhancer ABC_E1731

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proline oxidase-adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation. Lettieri Barbato D, et al. Cell Death Differ, 2014 Jan. PMID 24096872, Free PMC Article
    2. The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria. Buchalski B, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Mar 1. PMID 31821850, Free PMC Article
    3. Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase. Li X, et al. Biochim Biophys Acta, 2016 Feb. PMID 26655602, Free PMC Article
    4. Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. Kamiya A, et al. FEBS Lett, 2004 Dec 3. PMID 15581617
    5. A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Maynard TM, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14614146, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decreasing hepatic glycolate oxidase and HYPDH expression decreases oxalate excretion.
      Title: Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.
    2. The nutrient starvation elicits increased activity of mitochondrial proline oxidase/dehydrogenase (POX/PRODH) that is causal in triggering a ROS-dependent induction of ATGL.
      Title: Proline oxidase-adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation.
    3. study revealed that the expression of PO and PDH was regulated by HNF1alpha and HNF4alpha
      Title: Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH group of donors ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proline catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proline metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyproline dehydrogenase
    Names
    PO
    kidney and liver proline oxidase 1
    probable proline dehydrogenase 2
    probable proline oxidase 2
    proline oxidase 1
    proline oxidase-like protein
    NP_001405449.1
    NP_062419.2
    XP_006540284.1
    XP_006540285.1
    XP_006540286.1
    XP_006540287.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418520.1 → NP_001405449.1  hydroxyproline dehydrogenase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167970
      Related
      ENSMUST00000142514.8

    2. NM_019546.6 → NP_062419.2  hydroxyproline dehydrogenase isoform 1

      See identical proteins and their annotated locations for NP_062419.2

      Status: VALIDATED

      Source sequence(s)
      AC167970
      Consensus CDS
      CCDS21093.1
      UniProtKB/Swiss-Prot
      Q2V058, Q8VCZ9, Q9QX62
      Related
      ENSMUSP00000062214.7, ENSMUST00000058280.13
      Conserved Domains (1) summary
      pfam01619
      Location:218 → 439
      Pro_dh; Proline dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30193011..30212830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540221.2 → XP_006540284.1  hydroxyproline dehydrogenase isoform X1

      Conserved Domains (1) summary
      cl33545
      Location:80 → 439
      PutA_N; Proline utilization A N-terminal domain

    2. XM_006540222.3 → XP_006540285.1  hydroxyproline dehydrogenase isoform X2

      Conserved Domains (1) summary
      cl33545
      Location:47 → 372
      PutA_N; Proline utilization A N-terminal domain

    3. XM_006540224.4 → XP_006540287.1  hydroxyproline dehydrogenase isoform X4

      Conserved Domains (1) summary
      cl33545
      Location:47 → 373
      PutA_N; Proline utilization A N-terminal domain

    4. XM_006540223.1 → XP_006540286.1  hydroxyproline dehydrogenase isoform X3

      Conserved Domains (1) summary
      cl33545
      Location:13 → 403
      PutA_N; Proline utilization A N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCZ9.1 GenPept UniProtKB/Swiss-Prot:Q8VCZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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