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    Spink8 serine peptidase inhibitor, Kazal type 8 [ Mus musculus (house mouse) ]

    Gene ID: 78709, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Spink8provided by MGI
    Official Full Name
    serine peptidase inhibitor, Kazal type 8provided by MGI
    Primary source
    MGI:MGI:1925959
    See related
    Ensembl:ENSMUSG00000050074 AllianceGenome:MGI:1925959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C630041L24Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; hemolymphoid system; and liver. Orthologous to human SPINK8 (serine peptidase inhibitor Kazal type 8 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 783.7) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F2; 9 59.77 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109641271..109655696)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109812203..109826628)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene F-box and WD-40 domain protein 26 Neighboring gene F-box and WD-40 domain protein 27 Neighboring gene predicted gene, 40579 Neighboring gene predicted gene, 51691 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene NME/NM23 nucleoside diphosphate kinase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel epididymal protease inhibitors with Kazal or WAP family domain. Jalkanen J, et al. Biochem Biophys Res Commun, 2006 Oct 13. PMID 16930550
    2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    3. Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Sultana DA, et al. Blood, 2009 Mar 26. PMID 19164599, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor Kazal-type 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183136.2 → NP_898959.2  serine protease inhibitor Kazal-type 8 precursor

      See identical proteins and their annotated locations for NP_898959.2

      Status: VALIDATED

      Source sequence(s)
      AW455991, BC048588, CN843460
      Consensus CDS
      CCDS40777.1
      UniProtKB/Swiss-Prot
      Q09TK9
      UniProtKB/TrEMBL
      Q8C1F8
      Related
      ENSMUSP00000142586.2, ENSMUST00000198988.5
      Conserved Domains (1) summary
      cl00097
      Location:49 → 96
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      109641271..109655696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512398.5 → XP_006512461.1  serine protease inhibitor Kazal-type 8 isoform X1

      See identical proteins and their annotated locations for XP_006512461.1

      UniProtKB/Swiss-Prot
      Q09TK9
      UniProtKB/TrEMBL
      Q8C1F8
      Conserved Domains (1) summary
      cl00097
      Location:49 → 96
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09TK9.1 GenPept UniProtKB/Swiss-Prot:Q09TK9

    Gene LinkOut

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