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    Defa21 defensin, alpha, 21 [ Mus musculus (house mouse) ]

    Gene ID: 66298, updated on 23-Jun-2021

    Summary

    Official Symbol
    Defa21provided by MGI
    Official Full Name
    defensin, alpha, 21provided by MGI
    Primary source
    MGI:MGI:1913548
    See related
    Ensembl:ENSMUSG00000074447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Defcr2; Defcr21; 2010016B13Rik
    Expression
    Restricted expression toward large intestine adult (RPKM 2599.3) See more
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    Genomic context

    See Defa21 in Genome Data Viewer
    Location:
    8; 8 A2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (21515561..21516533)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21025545..21026517)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (22165224..22166196)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15056 Neighboring gene predicted gene 6040 Neighboring gene cDNA sequence AY761185 Neighboring gene predicted gene, 23142 Neighboring gene defensin, alpha, 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within defense response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response in mucosa IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in membrane disruption in other organism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-defensin 21
    Names
    defensin-related cryptdin-21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183253.3NP_899076.1  alpha-defensin 21 precursor

      See identical proteins and their annotated locations for NP_899076.1

      Status: VALIDATED

      Source sequence(s)
      AC161189
      Consensus CDS
      CCDS40264.1
      UniProtKB/Swiss-Prot
      Q8C1P2
      Related
      ENSMUSP00000076041.3, ENSMUST00000076754.3
      Conserved Domains (2) summary
      pfam00711
      Location:6690
      Defensin_beta; Beta defensin
      pfam00879
      Location:151
      Defensin_propep; Defensin propeptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      21515561..21516533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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