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    Mup1 major urinary protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 17840, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mup1provided by MGI
    Official Full Name
    major urinary protein 1provided by MGI
    Primary source
    MGI:MGI:97233
    See related
    Ensembl:ENSMUSG00000078683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ltn; Lvt; Mup; Up-; Mup-; Mup7; Up-1; Ltn-1; Mup-1; Mup-a; Mup10; Lvtn-1
    Expression
    Restricted expression toward liver adult (RPKM 1970.0) See more
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    Genomic context

    See Mup1 in Genome Data Viewer
    Location:
    4 B3; 4 32.85 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (60454011..60457959, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (60498012..60501960, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (60510884..60514832, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene major urinary protein, pseudogene 4 Neighboring gene major urinary protein, pseudogene 26 Neighboring gene major urinary protein, pseudogene 6 Neighboring gene major urinary protein, pseudogene 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables insulin-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables pheromone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pheromone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to food IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to lipid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to testosterone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in energy reserve metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heat generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in locomotor rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrion morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of lipid storage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to stilbenoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    major urinary protein 1
    Names
    MUP 1
    major urinary protein 10
    major urinary protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163010.1NP_001156482.1  major urinary protein 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001156482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      CR589880
      Consensus CDS
      CCDS18231.1
      UniProtKB/TrEMBL
      A2CEL1
      Related
      ENSMUSP00000103123.4, ENSMUST00000107499.4
      Conserved Domains (1) summary
      pfam00061
      Location:34170
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    2. NM_001163011.1NP_001156483.1  major urinary protein 1 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      CR589880
      Consensus CDS
      CCDS51188.1
      UniProtKB/TrEMBL
      A2CEL0
      Related
      ENSMUSP00000081596.5, ENSMUST00000084548.11
      Conserved Domains (1) summary
      pfam00061
      Location:34170
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    3. NM_031188.2NP_112465.2  major urinary protein 1 isoform b precursor

      See identical proteins and their annotated locations for NP_112465.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      CR589880
      Consensus CDS
      CCDS18231.1
      UniProtKB/TrEMBL
      A2CEL1
      Related
      ENSMUSP00000100077.4, ENSMUST00000103012.10
      Conserved Domains (1) summary
      pfam00061
      Location:34170
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      60454011..60457959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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