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    Adgra3 adhesion G protein-coupled receptor A3 [ Mus musculus (house mouse) ]

    Gene ID: 70693, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adgra3provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor A3provided by MGI
    Primary source
    MGI:MGI:1917943
    See related
    Ensembl:ENSMUSG00000029090 AllianceGenome:MGI:1917943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr125; Tem5-like; 3830613O22Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to act upstream of or within signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; craniocervical region bone; limb; metanephros; and sensory organ. Orthologous to human ADGRA3 (adhesion G protein-coupled receptor A3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 32.5), ovary adult (RPKM 24.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B3; 5 26.85 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (50117293..50216338, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (49959951..50058996, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13035 Neighboring gene predicted gene, 40299 Neighboring gene STARR-seq mESC enhancer starr_13036 Neighboring gene STARR-seq mESC enhancer starr_13037 Neighboring gene STARR-seq mESC enhancer starr_13038 Neighboring gene STARR-seq mESC enhancer starr_13039 Neighboring gene cytoskeleton associated protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13040 Neighboring gene predicted gene, 36702 Neighboring gene STARR-seq mESC enhancer starr_13041 Neighboring gene predicted gene, 40300

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice. Nybo ML, et al. FASEB J, 2023 Feb. PMID 36688818, Free PMC Article
    2. The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury. Pickering C, et al. BMC Neurosci, 2008 Oct 3. PMID 18834514, Free PMC Article
    3. Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM-LZ) and oncogenic KRAS in a mouse bone marrow transplantation model. Fu JF, et al. Int J Cancer, 2013 Oct 15. PMID 23564351
    4. Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for Cochlear Development and Hearing. Sun H, et al. Front Cell Dev Biol, 2021. PMID 34395423, Free PMC Article
    5. Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency. Spina E, et al. Nat Commun, 2022 Mar 17. PMID 35302059, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.
      Title: Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.
    2. upregulation of Gpr125 by cooperating MLL/AF10(OM-LZ) and KRASG12C promoted cell adhesion and contributed to the myeloid sarcoma formation.
      Title: Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM-LZ) and oncogenic KRAS in a mouse bone marrow transplantation model.
    3. Data show that GPR125 is specifically expressed in cells of the choroid plexus and is upregulated following traumatic brain injury.
      Title: The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury.
    4. GPR125+ multipotent adult stem cells generated derivatives of the three germ layers and contributed to chimaeric embryos, with concomitant downregulation of GPR125 during differentiation into GPR125- cells
      Title: Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor A3
    Names
    G protein coupled receptor Gpr125
    G protein-coupled receptor 125
    probable G-protein coupled receptor 125

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133911.1 → NP_598672.1  adhesion G protein-coupled receptor A3 precursor

      See identical proteins and their annotated locations for NP_598672.1

      Status: VALIDATED

      Source sequence(s)
      AK028929, AV238761, BC052391
      Consensus CDS
      CCDS51500.1
      UniProtKB/Swiss-Prot
      E9QK56, Q6PE67, Q7TT36, Q8VE71
      Related
      ENSMUSP00000030971.6, ENSMUST00000030971.7
      Conserved Domains (10) summary
      smart00082
      Location:178 → 212
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:238 → 330
      IG_like; Immunoglobulin like
      cd00116
      Location:73 → 155
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:72 → 95
      LRR_1; leucine-rich repeat [structural motif]
      pfam01825
      Location:688 → 732
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:352 → 405
      HRM; Hormone receptor domain
      pfam12799
      Location:119 → 158
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:74 → 130
      LRR_8; Leucine rich repeat
      cl11960
      Location:242 → 326
      Ig; Immunoglobulin domain
      cl21561
      Location:751 → 934
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      50117293..50216338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TT36.3 GenPept UniProtKB/Swiss-Prot:Q7TT36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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