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    Tbc1d2b TBC1 domain family, member 2B [ Mus musculus (house mouse) ]

    Gene ID: 67016, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tbc1d2bprovided by MGI
    Official Full Name
    TBC1 domain family, member 2Bprovided by MGI
    Primary source
    MGI:MGI:1914266
    See related
    Ensembl:ENSMUSG00000037410 AllianceGenome:MGI:1914266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1055; 1810061M12Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in cytosol. Is expressed in genitourinary system. Orthologous to human TBC1D2B (TBC1 domain family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 19.4), mammary gland adult (RPKM 17.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 E3.1; 9 47.48 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (90084100..90152861, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (90202047..90270772, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9030 Neighboring gene STARR-seq mESC enhancer starr_24885 Neighboring gene nuclear encoded tRNA lysine 18 (anticodon CTT) Neighboring gene RIKEN cDNA 9430062P05 gene Neighboring gene STARR-seq mESC enhancer starr_24886 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 7 Neighboring gene STARR-positive B cell enhancer ABC_E8860 Neighboring gene predicted gene 16200 Neighboring gene predicted gene, 30849 Neighboring gene predicted gene, 22717 Neighboring gene predicted gene, 22866

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413795.1 → NP_001400724.1  TBC1 domain family member 2B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140392, AC151735

    2. NM_194334.3 → NP_919315.2  TBC1 domain family member 2B isoform 1

      See identical proteins and their annotated locations for NP_919315.2

      Status: VALIDATED

      Source sequence(s)
      AC140392, AC151735
      Consensus CDS
      CCDS23401.1
      UniProtKB/Swiss-Prot
      Q2VPQ4, Q3U0J8, Q6PHN8, Q6ZPZ5
      Related
      ENSMUSP00000045413.8, ENSMUST00000041767.14
      Conserved Domains (4) summary
      cd01265
      Location:36 → 144
      PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
      pfam00169
      Location:38 → 136
      PH; PH domain
      pfam00566
      Location:710 → 878
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam16515
      Location:341 → 378
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      90084100..90152861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001778980.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U0J8.2 GenPept UniProtKB/Swiss-Prot:Q3U0J8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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