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    Aldh3a2 aldehyde dehydrogenase family 3, subfamily A2 [ Mus musculus (house mouse) ]

    Gene ID: 11671, updated on 23-Jun-2021

    Summary

    Official Symbol
    Aldh3a2provided by MGI
    Official Full Name
    aldehyde dehydrogenase family 3, subfamily A2provided by MGI
    Primary source
    MGI:MGI:1353452
    See related
    Ensembl:ENSMUSG00000010025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ahd; Ald; FAL; Ahd-; Ahd3; Aldh; Ahd-3; Aldh4; FALDH; Ahd-3r; Ahd3-r; Aldh4-r; AI194803
    Expression
    Ubiquitous expression in liver adult (RPKM 28.8), liver E18 (RPKM 13.6) and 28 other tissues See more
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    Genomic context

    See Aldh3a2 in Genome Data Viewer
    Location:
    11 B2; 11 37.96 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61114243..61158354, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61223417..61267528, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (61058257..61080629, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S13, pseudogene 5 Neighboring gene aldehyde dehydrogenase family 3, subfamily A1 Neighboring gene solute carrier family 47, member 2 Neighboring gene predicted gene, 25929 Neighboring gene solute carrier family 47, member 1 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aldehyde dehydrogenase family 3 member A2
    Names
    alcohol dehydrogenase family 3, subfamily A2
    aldehyde dehydrogenase 3
    aldehyde dehydrogenase 4, liver microsomal (class 3) regulator
    fatty aldehyde dehydrogenase variant form
    NP_001318043.1
    NP_001318044.1
    NP_031463.2
    XP_006532093.1
    XP_006532094.1
    XP_030101342.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331114.1NP_001318043.1  aldehyde dehydrogenase family 3 member A2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL672172
      Conserved Domains (1) summary
      cd07132
      Location:5444
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    2. NM_001331115.1NP_001318044.1  aldehyde dehydrogenase family 3 member A2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL672172
      Conserved Domains (1) summary
      cl11961
      Location:1374
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
    3. NM_007437.5NP_031463.2  aldehyde dehydrogenase family 3 member A2 isoform 2

      See identical proteins and their annotated locations for NP_031463.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon resulting in a frameshift, and differs in the 3' UTR. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK159246, AK163040, AK169157, AV373678
      Consensus CDS
      CCDS24809.1
      UniProtKB/Swiss-Prot
      P47740
      Related
      ENSMUSP00000073764.8, ENSMUST00000074127.14
      Conserved Domains (1) summary
      cd07132
      Location:5444
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RNA

    1. NR_138545.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' exon structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL646093, AL672172

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61114243..61158354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532031.5XP_006532094.1  aldehyde dehydrogenase family 3 member A2 isoform X2

      Conserved Domains (1) summary
      cd07132
      Location:5444
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    2. XM_030245482.2XP_030101342.1  aldehyde dehydrogenase family 3 member A2 isoform X3

      Conserved Domains (1) summary
      cl11961
      Location:1374
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
    3. XM_006532030.5XP_006532093.1  aldehyde dehydrogenase family 3 member A2 isoform X1

      UniProtKB/TrEMBL
      B1AV77
      Related
      ENSMUSP00000104355.3, ENSMUST00000108715.3
      Conserved Domains (1) summary
      cd07132
      Location:5444
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RNA

    1. XR_388332.5 RNA Sequence

    2. XR_388331.5 RNA Sequence

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