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    Cyp2j13 cytochrome P450, family 2, subfamily j, polypeptide 13 [ Mus musculus (house mouse) ]

    Gene ID: 230459, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Cyp2j13provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily j, polypeptide 13provided by MGI
    Primary source
    MGI:MGI:2385197
    See related
    Ensembl:ENSMUSG00000028571 AllianceGenome:MGI:2385197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable heme binding activity; isomerase activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway; linoleic acid metabolic process; and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 1.3) and kidney adult (RPKM 0.1) See more
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    Genomic context

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    Location:
    4 C5; 4 44.22 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (95930897..95965803, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (96042660..96077566, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1032 Neighboring gene FGGY carbohydrate kinase domain containing Neighboring gene STARR-seq mESC enhancer starr_10810 Neighboring gene STARR-seq mESC enhancer starr_10811 Neighboring gene STARR-seq mESC enhancer starr_10812 Neighboring gene STARR-seq mESC enhancer starr_10813 Neighboring gene STARR-seq mESC enhancer starr_10814 Neighboring gene RIKEN cDNA 9530080O11 gene Neighboring gene STARR-positive B cell enhancer ABC_E1647 Neighboring gene STARR-seq mESC enhancer starr_10816 Neighboring gene hook microtubule tethering protein 1 Neighboring gene STARR-seq mESC enhancer starr_10817 Neighboring gene STARR-seq mESC enhancer starr_10818 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 6 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 12 Neighboring gene STARR-seq mESC enhancer starr_10819 Neighboring gene STARR-seq mESC enhancer starr_10820 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonic acid 11,12-epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonic acid 14,15-epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonic acid epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables linoleic acid epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in icosanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily j, polypeptide 13
    Names
    cytochrome P450, 2j13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346539.1 → NP_001333468.1  cytochrome P450, family 2, subfamily j, polypeptide 13 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL772212, AL772395
      Consensus CDS
      CCDS84755.1
      UniProtKB/TrEMBL
      B1AWM5, Q91W71
      Related
      ENSMUSP00000095587.3, ENSMUST00000097973.3

    2. NM_001346540.1 → NP_001333469.1  cytochrome P450, family 2, subfamily j, polypeptide 13 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 3, which is shorter, and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL772212, AL772395
      Consensus CDS
      CCDS89780.1
      UniProtKB/TrEMBL
      B1AWM4, Q91W71
      Related
      ENSMUSP00000102693.3, ENSMUST00000107078.9

    3. NM_145548.4 → NP_663523.2  cytochrome P450, family 2, subfamily j, polypeptide 13 isoform 1

      See identical proteins and their annotated locations for NP_663523.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the longest transcript and encodes the longest isoform.
      Source sequence(s)
      AL772212, AL772395
      Consensus CDS
      CCDS18368.1
      UniProtKB/TrEMBL
      Q3UNV4
      Related
      ENSMUSP00000030305.7, ENSMUST00000030305.13
      Conserved Domains (1) summary
      pfam00067
      Location:44 → 475
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      95930897..95965803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502935.3 → XP_006502998.1  cytochrome P450, family 2, subfamily j, polypeptide 13 isoform X1

      Conserved Domains (1) summary
      pfam00067
      Location:44 → 447
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version

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