Afdn afadin, adherens junction formation factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Afdnprovided by MGI
Official Full Name: afadin, adherens junction formation factorprovided by MGI
Primary source: MGI:MGI:1314653
See related: Ensembl:ENSMUSG00000068036 AllianceGenome:MGI:1314653
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AF6; Af-6; Gm314; Mllt4; Afadin; I-afadin; S-afadin; 5033403D15Rik
Summary: Enables cell adhesion molecule binding activity. Involved in cell-cell adhesion mediated by cadherin; establishment of protein localization to plasma membrane; and pore complex assembly. Acts upstream of or within several processes, including adherens junction maintenance; nervous system development; and regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including adherens junction; apical junction complex; and apical part of cell. Part of pore complex. Is expressed in eye; genitourinary system; and nervous system. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 14.2), whole brain E14.5 (RPKM 13.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A1- A2; 17 8.95 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (13980735..14126059)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (13760391..13905798)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases.
Title: Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases.
Rap1 regulates lumen continuity via Afadin in renal epithelia.
Title: Rap1 regulates lumen continuity via Afadin in renal epithelia.
s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons.
Title: s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons.
Dynamic interplay between Afadin(S1795) phosphorylation and diet regulates glucose homeostasis in obese mice.
Title: Dynamic interplay between Afadin(S1795) phosphorylation and diet regulates glucose homeostasis in obese mice.
Cold-induction of afadin in brown fat supports its thermogenic capacity.
Title: Cold-induction of afadin in brown fat supports its thermogenic capacity.
Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection.
Title: Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection.
Afadin regulates actomyosin organization through alphaE-catenin at adherens junctions.
Title: Afadin regulates actomyosin organization through αE-catenin at adherens junctions.
Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1.
Title: Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1.
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.
Title: mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.
Afadin binding with interaction partners in adipocytes, among which HDAC6 preferentially interacts with phosphorylated Afadin and acts as a key intermediate to suppress insulin receptor protein levels.
Title: Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables LIM domain binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adherens junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite arborization	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial intestinal barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroepithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mini excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cell junction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within radial glial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of oligodendrocyte progenitor proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within telencephalon development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical junction complex	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
colocalizes_with excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of pore complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of pore complex	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in somatodendritic compartment	ISO Inferred from Sequence Orthology more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: afadin

Names: myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4; protein Af-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010806.1 → NP_034936.1 afadin

See identical proteins and their annotated locations for NP_034936.1

Status: VALIDATED

Source sequence(s)

AF172447, BI991173, BQ929757, BU611478, CB181965, CF538789, CJ165098, CK637291, CN529812, CN537179, CN538841, CO042367, CO433521

Consensus CDS

CCDS49955.1

UniProtKB/Swiss-Prot

Q9QZQ1

UniProtKB/TrEMBL

E9Q852

Related

ENSMUSP00000118318.2, ENSMUST00000139666.8

Conserved Domains (7) summary

cd01781
Location:247 → 346

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd00060
Location:417 → 499

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:611 → 932

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

pfam00595
Location:1008 → 1090

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam03064
Location:1592 → 1678

U79_P34; HSV U79 / HCMV P34

pfam15346
Location:1525 → 1668

ARGLU; Arginine and glutamate-rich 1

cl00155
Location:20 → 131

UBQ; Ubiquitin-like proteins

RNA

NR_151731.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC155253, AC174800, CT030652

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

13980735..14126059

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523752.4 → XP_006523815.1 afadin isoform X1

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:418 → 500

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:612 → 940

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1016 → 1098

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1599 → 1698

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1465 → 1717

DUF5401; Family of unknown function (DUF5401)
XM_006523763.4 → XP_006523826.1 afadin isoform X16

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:418 → 500

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:612 → 940

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1016 → 1098

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1599 → 1698

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1465 → 1717

DUF5401; Family of unknown function (DUF5401)
XM_006523755.4 → XP_006523818.1 afadin isoform X4

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

PTZ00121
Location:1509 → 1694

PTZ00121; MAEBL; Provisional

cd00060
Location:418 → 500

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:612 → 940

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1016 → 1098

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1603 → 1697

ARGLU; Arginine and glutamate-rich 1
XM_030249527.2 → XP_030105387.1 afadin isoform X17

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

PTZ00121
Location:1509 → 1694

PTZ00121; MAEBL; Provisional

cd00060
Location:418 → 500

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:612 → 940

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1016 → 1098

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1603 → 1697

ARGLU; Arginine and glutamate-rich 1
XM_006523759.4 → XP_006523822.1 afadin isoform X10

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:418 → 500

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:612 → 940

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1016 → 1098

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam05672
Location:1602 → 1686

MAP7; MAP7 (E-MAP-115) family

pfam17380
Location:1485 → 1705

DUF5401; Family of unknown function (DUF5401)
XM_006523764.4 → XP_006523827.1 afadin isoform X19

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:418 → 500

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:612 → 940

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1016 → 1098

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam05672
Location:1602 → 1686

MAP7; MAP7 (E-MAP-115) family

pfam17380
Location:1485 → 1705

DUF5401; Family of unknown function (DUF5401)
XM_006523757.4 → XP_006523820.1 afadin isoform X6

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:418 → 500

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:612 → 933

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1009 → 1091

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1592 → 1691

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1458 → 1710

DUF5401; Family of unknown function (DUF5401)
XM_006523766.4 → XP_006523829.1 afadin isoform X18

UniProtKB/TrEMBL

E9Q852

Related

ENSMUSP00000114485.2, ENSMUST00000137708.8

Conserved Domains (7) summary

cd00060
Location:418 → 500

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:612 → 933

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1009 → 1091

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1592 → 1691

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1458 → 1710

DUF5401; Family of unknown function (DUF5401)
XM_006523760.4 → XP_006523823.1 afadin isoform X11

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:385 → 485

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:597 → 925

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1001 → 1083

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1584 → 1683

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1450 → 1702

DUF5401; Family of unknown function (DUF5401)
XM_030249528.2 → XP_030105388.1 afadin isoform X21

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:385 → 485

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:597 → 925

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1001 → 1083

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam05672
Location:1587 → 1671

MAP7; MAP7 (E-MAP-115) family

pfam17380
Location:1470 → 1690

DUF5401; Family of unknown function (DUF5401)
XM_030249526.2 → XP_030105386.1 afadin isoform X14

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:385 → 485

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:597 → 918

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:248 → 348

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:994 → 1076

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1577 → 1676

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1443 → 1695

DUF5401; Family of unknown function (DUF5401)
XM_006523754.4 → XP_006523817.1 afadin isoform X3

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:417 → 499

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:611 → 939

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:247 → 347

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1015 → 1097

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1598 → 1697

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1464 → 1716

DUF5401; Family of unknown function (DUF5401)
XM_017317275.3 → XP_017172764.1 afadin isoform X8

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:417 → 499

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:611 → 932

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:247 → 347

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 132

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1008 → 1090

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1591 → 1690

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1457 → 1709

DUF5401; Family of unknown function (DUF5401)
XM_006523753.4 → XP_006523816.1 afadin isoform X2

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:417 → 499

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:611 → 939

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:247 → 347

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 131

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1015 → 1097

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1598 → 1697

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1464 → 1716

DUF5401; Family of unknown function (DUF5401)
XM_006523765.4 → XP_006523828.1 afadin isoform X20

UniProtKB/TrEMBL

E9Q852, E9Q9C3

Related

ENSMUSP00000119153.2, ENSMUST00000137784.8

Conserved Domains (7) summary

cd00060
Location:417 → 499

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:611 → 939

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:247 → 347

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 131

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1015 → 1097

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam05672
Location:1601 → 1685

MAP7; MAP7 (E-MAP-115) family

pfam17380
Location:1484 → 1704

DUF5401; Family of unknown function (DUF5401)
XM_006523758.4 → XP_006523821.1 afadin isoform X7

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:417 → 499

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:611 → 932

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:247 → 347

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 131

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1008 → 1090

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1591 → 1690

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1457 → 1709

DUF5401; Family of unknown function (DUF5401)
XM_036160347.1 → XP_036016240.1 afadin isoform X12

UniProtKB/TrEMBL

E9Q852

Conserved Domains (6) summary

cd00060
Location:384 → 484

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:596 → 924

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:247 → 347

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 131

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1000 → 1082

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15709
Location:1507 → 1681

DUF4670; Domain of unknown function (DUF4670)
XM_006523756.4 → XP_006523819.1 afadin isoform X5

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:416 → 498

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:610 → 938

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:246 → 346

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 131

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1014 → 1096

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1597 → 1696

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1463 → 1715

DUF5401; Family of unknown function (DUF5401)
XM_017317276.3 → XP_017172765.1 afadin isoform X9

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:416 → 498

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:610 → 931

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:246 → 346

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 131

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:1007 → 1089

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1590 → 1689

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1456 → 1708

DUF5401; Family of unknown function (DUF5401)
XM_036160348.1 → XP_036016241.1 afadin isoform X13

UniProtKB/TrEMBL

E9Q852

Conserved Domains (6) summary

cd00060
Location:383 → 483

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:595 → 923

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:246 → 346

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 131

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:999 → 1081

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15709
Location:1506 → 1680

DUF4670; Domain of unknown function (DUF4670)
XM_006523762.4 → XP_006523825.1 afadin isoform X15

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:383 → 483

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:595 → 916

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:246 → 346

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 131

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:992 → 1074

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam15346
Location:1575 → 1674

ARGLU; Arginine and glutamate-rich 1

pfam17380
Location:1441 → 1693

DUF5401; Family of unknown function (DUF5401)
XM_006523767.4 → XP_006523830.1 afadin isoform X22

UniProtKB/TrEMBL

E9Q852

Conserved Domains (7) summary

cd00060
Location:383 → 483

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd15471
Location:595 → 916

Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

cd01781
Location:246 → 346

RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin

cd01782
Location:20 → 131

RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin

pfam00595
Location:992 → 1074

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam05672
Location:1578 → 1662

MAP7; MAP7 (E-MAP-115) family

pfam17380
Location:1461 → 1681

DUF5401; Family of unknown function (DUF5401)