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    Saraf store-operated calcium entry-associated regulatory factor [ Mus musculus (house mouse) ]

    Gene ID: 67887, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Sarafprovided by MGI
    Official Full Name
    store-operated calcium entry-associated regulatory factorprovided by MGI
    Primary source
    MGI:MGI:1915137
    See related
    Ensembl:ENSMUSG00000031532 AllianceGenome:MGI:1915137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem66; 1810045K07Rik
    Summary
    Predicted to be involved in regulation of store-operated calcium entry. Predicted to act upstream of or within calcium ion transport. Predicted to be located in endoplasmic reticulum and endoplasmic reticulum-plasma membrane contact site. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in nervous system; nose; and tooth. Orthologous to human SARAF (store-operated calcium entry associated regulatory factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 156.6), ovary adult (RPKM 97.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A4; 8 20.9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34621733..34638001)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (34154579..34170847)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene membrane bound O-acyltransferase domain containing 4 Neighboring gene predicted gene, 39158 Neighboring gene leptin receptor overlapping transcript-like 1 Neighboring gene STARR-positive B cell enhancer mm9_chr8:35217440-35217740 Neighboring gene STARR-positive B cell enhancer ABC_E10495 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:35226466-35226653 Neighboring gene microRNA 6395 Neighboring gene predicted gene, 33638 Neighboring gene STARR-positive B cell enhancer ABC_E4999 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:35279146-35279346 Neighboring gene predicted gene 29243

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Store-operated calcium entry-associated regulatory factor regulates airway inflammation and airway remodeling in asthma mice models. Wang YM, et al. Am J Physiol Lung Cell Mol Physiol, 2021 Sep 1. PMID 34231388
    2. Saraf-dependent activation of mTORC1 regulates cardiac growth. Sanlialp A, et al. J Mol Cell Cardiol, 2020 Apr. PMID 32173353
    3. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Lodder EM, et al. Circ Cardiovasc Genet, 2014 Dec. PMID 25217174
    4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Store-operated calcium entry-associated regulatory factor regulates airway inflammation and airway remodeling in asthma mice models.
      Title: Store-operated calcium entry-associated regulatory factor regulates airway inflammation and airway remodeling in asthma mice models.
    2. Saraf-dependent activation of mTORC1 regulates cardiac growth.
      Title: Saraf-dependent activation of mTORC1 regulates cardiac growth.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    store-operated calcium entry-associated regulatory factor
    Names
    SOCE-associated regulatory factor
    transmembrane protein 66

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026432.4 → NP_080708.4  store-operated calcium entry-associated regulatory factor precursor

      Status: VALIDATED

      Source sequence(s)
      AI841528, AK007787, BY135425
      Consensus CDS
      CCDS22240.1
      UniProtKB/Swiss-Prot
      Q8C2F1, Q8C6G7, Q8N9S4, Q8R233, Q8R3Q0, Q9D8R1
      UniProtKB/TrEMBL
      A0A0R4J0D1
      Related
      ENSMUSP00000033933.7, ENSMUST00000033933.8
      Conserved Domains (1) summary
      pfam06682
      Location:25 → 334
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      34621733..34638001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3Q0.2 GenPept UniProtKB/Swiss-Prot:Q8R3Q0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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