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    Cnih4 cornichon family AMPA receptor auxiliary protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 98417, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cnih4provided by MGI
    Official Full Name
    cornichon family AMPA receptor auxiliary protein 4provided by MGI
    Primary source
    MGI:MGI:1925828
    See related
    Ensembl:ENSMUSG00000062169 AllianceGenome:MGI:1925828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CNIH-4; HSPC163; D530030D03Rik; E430023H19Rik
    Summary
    Predicted to enable CCR5 chemokine receptor binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment. Predicted to be active in COPII-coated ER to Golgi transport vesicle and endoplasmic reticulum membrane. Orthologous to human CNIH4 (cornichon family AMPA receptor auxiliary protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 8.3), placenta adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H4; 1 84.53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180977437..180996559)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181150366..181168994)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene degenerative spermatocyte homolog 1 pseudogene Neighboring gene fibroblast growth factor receptor 3, pseudogene Neighboring gene nuclear VCP-like Neighboring gene STARR-positive B cell enhancer ABC_E2593 Neighboring gene STARR-positive B cell enhancer ABC_E2026 Neighboring gene WD repeat domain 26 Neighboring gene predicted gene, 50602 Neighboring gene predicted gene, 38664 Neighboring gene STARR-positive B cell enhancer ABC_E5875

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility. Dil S, et al. Dev Biol, 2023 Apr. PMID 36657507
    2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility.
      Title: Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR5 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein cornichon homolog 4
    Names
    cornichon homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030131.3 → NP_084407.1  protein cornichon homolog 4

      See identical proteins and their annotated locations for NP_084407.1

      Status: VALIDATED

      Source sequence(s)
      AC113084, AK021301, AW050376
      Consensus CDS
      CCDS15582.1
      UniProtKB/Swiss-Prot
      Q3TNM6, Q9CX13
      Related
      ENSMUSP00000115772.2, ENSMUST00000134115.8
      Conserved Domains (1) summary
      pfam03311
      Location:3 → 130
      Cornichon; Cornichon protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      180977437..180996559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238890.4 → XP_011237192.1  protein cornichon homolog 4 isoform X1

      Conserved Domains (1) summary
      pfam03311
      Location:4 → 94
      Cornichon; Cornichon protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CX13.1 GenPept UniProtKB/Swiss-Prot:Q9CX13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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