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    Adgra1 adhesion G protein-coupled receptor A1 [ Mus musculus (house mouse) ]

    Gene ID: 52389, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adgra1provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor A1provided by MGI
    Primary source
    MGI:MGI:1277167
    See related
    Ensembl:ENSMUSG00000025475 AllianceGenome:MGI:1277167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr123; D7Ertd680e; 2900059M17Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Located in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including adrenal gland; central nervous system; eye; and genitourinary system. Orthologous to human ADGRA1 (adhesion G protein-coupled receptor A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 8.4), frontal lobe adult (RPKM 7.5) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adgra1 in Genome Data Viewer
    Location:
    7 F4; 7 84.89 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139414014..139458004)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139834097..139878088)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L24 pseudogene Neighboring gene microRNA 6401 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene kinase non-catalytic C-lobe domain (KIND) containing 1 Neighboring gene STARR-seq mESC enhancer starr_20433

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased Anxiety-like Behaviors in Adgra1(-/-) Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3β and MEK/ERK Pathways. Zhang XH, et al. Neuroscience, 2022 Nov 1. PMID 36115515
    2. ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus-pituitary-thyroid axis in male mice. Zhang XH, et al. Cell Death Dis, 2021 Apr 6. PMID 33824276, Free PMC Article
    3. Method for systematic targeted isolation of homologous cDNA fragments in a multiplex format. Ohara R, et al. Biotechniques, 2004 May. PMID 15152599
    4. Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution. Pandya NJ, et al. Sci Rep, 2017 Sep 21. PMID 28935861, Free PMC Article
    5. Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: implication for regulation by IL-1beta. Ashley RL, et al. Endocrinology, 2010 Sep. PMID 20660068

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased Anxiety-like Behaviors in Adgra1(-/-) Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3beta and MEK/ERK Pathways.
      Title: Increased Anxiety-like Behaviors in Adgra1(-/-) Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3β and MEK/ERK Pathways.
    2. ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus-pituitary-thyroid axis in male mice.
      Title: ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus-pituitary-thyroid axis in male mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor A1
    Names
    G protein coupled receptor Gpr123
    G protein-coupled receptor 123
    probable G-protein coupled receptor 123

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177469.3 → NP_803420.2  adhesion G protein-coupled receptor A1

      See identical proteins and their annotated locations for NP_803420.2

      Status: VALIDATED

      Source sequence(s)
      AK082207, BC056493, BE651866, BG083237
      Consensus CDS
      CCDS40171.1
      UniProtKB/Swiss-Prot
      Q8C4G9, Q8CC05
      UniProtKB/TrEMBL
      Q76JQ1
      Related
      ENSMUSP00000026548.8, ENSMUST00000026548.14
      Conserved Domains (1) summary
      cl21561
      Location:29 → 299
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139414014..139458004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536203.5 → XP_006536266.1  adhesion G protein-coupled receptor A1 isoform X1

      See identical proteins and their annotated locations for XP_006536266.1

      UniProtKB/TrEMBL
      Q76JQ1
      Conserved Domains (2) summary
      cd14964
      Location:17 → 41
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:14 → 325
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C4G9.1 GenPept UniProtKB/Swiss-Prot:Q8C4G9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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