Timd2 T cell immunoglobulin and mucin domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Timd2provided by MGI
Official Full Name: T cell immunoglobulin and mucin domain containing 2provided by MGI
Primary source: MGI:MGI:2159681
See related: Ensembl:ENSMUSG00000040413 AllianceGenome:MGI:2159681
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G9D3; Tim2; TIM-2
Summary: Enables ferritin receptor activity. Acts upstream of or within iron ion transport. Located in cell surface. Is expressed in 4-cell stage embryo; liver; liver left lobe; liver right lobe; and metanephros. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 18.2), liver adult (RPKM 17.7) and 4 other tissues See more
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Genomic context

Location:: 11 B1.1; 11 28.05 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (46559787..46597934, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (46668960..46707107, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We concluded that pro-apoptotic effects on Th1 population through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica.
Title: Tim-2 up-regulation and galectin-9-Tim-3 pathway activation in Th2-biased response in Schistosoma japonicum infection in mice.
TIM-2 signaling influences both proliferation and antibody production of B cells during the early phase of collagen-induced arthritis
Title: Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells.
TIM-2 can function as an iron uptake pathway.
Title: Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells.
The increased expression of the pro-inflammatory and proapoptotic genes, a higher number of apoptotic cells, and increased injury and mortality of the TIM2-deficient mice suggest a protective role of TIM2 in cisplatin-induced nephrotoxicity.
Title: TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity.
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.
Title: TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.
There are Tim2-binding molecules on hepatocytes. Tim2-hFc inhibited differentiation & proliferation of hepatocytes in fetal liver primary culture. Down-regulation of Tim2 expression by siRNA enhanced expression of liver differentiation marker genes.
Title: Tim2 is expressed in mouse fetal hepatocytes and regulates their differentiation.
The mTIM-1 structure identified a homophilic TIM-TIM adhesion interaction, whereas the mTIM-2 domain formed a dimer that prevented homophilic binding.
Title: Structures of T Cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family.
expression of TIM-2 significantly impairs the induction of NFAT and AP-1 transcriptional reporters
Title: Cutting edge: inhibition of T cell activation by TIM-2.
Tim-2 negatively regulates the Th2 differentiation of Ag-primed T-cells and the development of EC during the effector phase.
Title: T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AU019662 (e-PCR)
- UniSTS:185876

NoName (e-PCR)
- UniSTS:236565

Timd2 (e-PCR), detects polymorphism
- UniSTS:536608

Timd2 (e-PCR), detects polymorphism
- UniSTS:536609

RH136489 (e-PCR)
- UniSTS:210473

Timd1 (e-PCR), detects polymorphism
- UniSTS:239192

RH126308 (e-PCR)
- UniSTS:163016

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ferritin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables virus receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within iron ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis, engulfment	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mast cell activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T-cell immunoglobulin and mucin domain-containing protein 2

Names: T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; TIMD-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161355.1 → NP_001154827.1 T-cell immunoglobulin and mucin domain-containing protein 2 precursor

See identical proteins and their annotated locations for NP_001154827.1

Status: VALIDATED

Description

Transcript Variant: This variant (1), variant 2 and variant 3 encode the same protein.

Source sequence(s)

AK145630, AK163225, AK166877, CB953226

Consensus CDS

CCDS24582.1

UniProtKB/Swiss-Prot

Q8R183, Q8VBW0

UniProtKB/TrEMBL

A8C1R4

Related

ENSMUSP00000104848.3, ENSMUST00000109225.9

Conserved Domains (1) summary

pfam07686
Location:30 → 119

V-set; Immunoglobulin V-set domain
NM_001161356.1 → NP_001154828.1 T-cell immunoglobulin and mucin domain-containing protein 2 precursor

See identical proteins and their annotated locations for NP_001154828.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 5' UTR, as compared to variant 1.

Source sequence(s)

AB009015, AK145630, AK166877

Consensus CDS

CCDS24582.1

UniProtKB/Swiss-Prot

Q8R183, Q8VBW0

UniProtKB/TrEMBL

A8C1R4

Related

ENSMUSP00000131540.2, ENSMUST00000169584.8

Conserved Domains (1) summary

pfam07686
Location:30 → 119

V-set; Immunoglobulin V-set domain
NM_134249.5 → NP_599010.4 T-cell immunoglobulin and mucin domain-containing protein 2 precursor

See identical proteins and their annotated locations for NP_599010.4

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1.

Source sequence(s)

AK145630, AK163225, AK166877, BY731803

Consensus CDS

CCDS24582.1

UniProtKB/Swiss-Prot

Q8R183, Q8VBW0

UniProtKB/TrEMBL

A8C1R4

Related

ENSMUSP00000060891.7, ENSMUST00000055102.13

Conserved Domains (1) summary

pfam07686
Location:30 → 119

V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

46559787..46597934 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245625.1 → XP_030101485.1 T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8R183, Q8VBW0

UniProtKB/TrEMBL

A8C1R4

Conserved Domains (1) summary

pfam07686
Location:30 → 119

V-set; Immunoglobulin V-set domain
XM_030245624.1 → XP_030101484.1 T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8R183, Q8VBW0

UniProtKB/TrEMBL

A8C1R4

Conserved Domains (1) summary

pfam07686
Location:30 → 119

V-set; Immunoglobulin V-set domain