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    F13a1 coagulation factor XIII, A1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 74145, updated on 23-Jun-2021

    Summary

    Official Symbol
    F13a1provided by MGI
    Official Full Name
    coagulation factor XIII, A1 subunitprovided by MGI
    Primary source
    MGI:MGI:1921395
    See related
    Ensembl:ENSMUSG00000039109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F13a; AI462306; 1200014I03Rik
    Summary
    This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in bladder adult (RPKM 12.1), mammary gland adult (RPKM 11.7) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See F13a1 in Genome Data Viewer
    Location:
    13; 13 A3.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (37051150..37234220, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (36867178..37050244, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (36959047..37142113, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38636 Neighboring gene predicted gene, 30177 Neighboring gene neuritin 1 Neighboring gene predicted gene, 30489 Neighboring gene predicted gene, 30240 Neighboring gene predicted gene, 30549 Neighboring gene Rho GTPase activating protein 20 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-glutamine gamma-glutamyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-glutamine gamma-glutamyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood coagulation, fibrin clot formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in blood coagulation, fibrin clot formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood coagulation, fibrin clot formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide cross-linking IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within peptide cross-linking IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    coagulation factor XIII A chain
    Names
    coagulation factor XIII, alpha subunit
    coagulation factor XIIIa
    protein-glutamine gamma-glutamyltransferase A chain
    transglutaminase A chain
    NP_001159863.1
    NP_083060.2
    XP_036014090.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166391.1NP_001159863.1  coagulation factor XIII A chain

      See identical proteins and their annotated locations for NP_001159863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK030914, AK049092, AV249730, BM239113
      Consensus CDS
      CCDS26456.1
      UniProtKB/Swiss-Prot
      Q8BH61
      UniProtKB/TrEMBL
      Q3V3W7
      Related
      ENSMUSP00000128316.2, ENSMUST00000164727.8
      Conserved Domains (4) summary
      smart00460
      Location:309400
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:280408
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:47164
      Transglut_N; Transglutaminase family
      pfam00927
      Location:519623
      Transglut_C; Transglutaminase family, C-terminal ig like domain
    2. NM_028784.3NP_083060.2  coagulation factor XIII A chain

      See identical proteins and their annotated locations for NP_083060.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK049092, AV249730, BM239113
      Consensus CDS
      CCDS26456.1
      UniProtKB/Swiss-Prot
      Q8BH61
      Related
      ENSMUSP00000048667.9, ENSMUST00000037491.11
      Conserved Domains (4) summary
      smart00460
      Location:309400
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:280408
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:47164
      Transglut_N; Transglutaminase family
      pfam00927
      Location:519623
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      37051150..37234220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158197.1XP_036014090.1  coagulation factor XIII A chain isoform X1

      Conserved Domains (2) summary
      smart00460
      Location:67158
      TGc; Transglutaminase/protease-like homologues
      pfam00927
      Location:277381
      Transglut_C; Transglutaminase family, C-terminal ig like domain
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