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    Fgf11 fibroblast growth factor 11 [ Mus musculus (house mouse) ]

    Gene ID: 14166, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fgf11provided by MGI
    Official Full Name
    fibroblast growth factor 11provided by MGI
    Primary source
    MGI:MGI:109167
    See related
    Ensembl:ENSMUSG00000042826 AllianceGenome:MGI:109167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fhf3; Fgf1d; Fhf-3; Fgf-11
    Summary
    Predicted to enable sodium channel regulator activity. Predicted to be involved in regulation of voltage-gated sodium channel activity. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human FGF11 (fibroblast growth factor 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 10.9), CNS E18 (RPKM 7.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 42.88 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69686894..69693775, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69796068..69802944, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_29866 Neighboring gene STARR-seq mESC enhancer starr_29867 Neighboring gene cholinergic receptor nicotinic beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E7006 Neighboring gene RIKEN cDNA G630025P09 gene Neighboring gene transmembrane protein 102 Neighboring gene SPEM family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Silencing of hypothalamic FGF11 prevents diet-induced obesity. Cho JH, et al. Mol Brain, 2022 Sep 5. PMID 36064426, Free PMC Article
    2. Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse. Tejedor G, et al. Sci Rep, 2020 Feb 27. PMID 32107392, Free PMC Article
    3. FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPARγ regulators. Lee KW, et al. FEBS Open Bio, 2019 Apr. PMID 30984550, Free PMC Article
    4. T2DM inhibition of endothelial miR-342-3p facilitates angiogenic dysfunction via repression of FGF11 signaling. Cheng S, et al. Biochem Biophys Res Commun, 2018 Sep 3. PMID 29852165
    5. FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells. Zhong W, et al. Mol Reprod Dev, 2006 May. PMID 16470835

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing of hypothalamic FGF11 prevents diet-induced obesity.
      Title: Silencing of hypothalamic FGF11 prevents diet-induced obesity.
    2. Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse.
      Title: Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse.
    3. FGF11 indirectly controls the expression of PPARgamma through modifying the expression of multiple PPARgamma regulators, thereby mediating adipogenesis.
      Title: FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPARγ regulators.
    4. endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration. From a mechanistic standpoint, miR-342-3p promoted the transactivation of fibroblast growth factor 11 (FGF11) by directly targeting its 3' untranslated regions (3'UTRs).
      Title: T2DM inhibition of endothelial miR-342-3p facilitates angiogenic dysfunction via repression of FGF11 signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor 11
    Names
    fibroblast growth factor 1d
    fibroblast growth factor homologous factor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291104.2 → NP_001278033.1  fibroblast growth factor 11 isoform 2

      See identical proteins and their annotated locations for NP_001278033.1

      Status: VALIDATED

      Source sequence(s)
      AL603707, U66203
      Consensus CDS
      CCDS70218.1
      UniProtKB/TrEMBL
      Q6NXW2
      Related
      ENSMUSP00000011285.5, ENSMUST00000011285.11
      Conserved Domains (1) summary
      cl00060
      Location:69 → 171
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    2. NM_001362623.1 → NP_001349552.1  fibroblast growth factor 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL603707
      Consensus CDS
      CCDS24911.1
      UniProtKB/Swiss-Prot
      P70378, Q5F291
      UniProtKB/TrEMBL
      A0A7U3L4H2
      Related
      ENSMUSP00000099645.2, ENSMUST00000102585.2
      Conserved Domains (1) summary
      smart00442
      Location:69 → 199
      FGF; Acidic and basic fibroblast growth factor family

    3. NM_001362624.1 → NP_001349553.1  fibroblast growth factor 11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL603707
      Conserved Domains (1) summary
      smart00442
      Location:69 → 199
      FGF; Acidic and basic fibroblast growth factor family

    4. NM_010198.3 → NP_034328.1  fibroblast growth factor 11 isoform 1

      See identical proteins and their annotated locations for NP_034328.1

      Status: VALIDATED

      Source sequence(s)
      AL603707, U66203
      Consensus CDS
      CCDS24911.1
      UniProtKB/Swiss-Prot
      P70378, Q5F291
      UniProtKB/TrEMBL
      A0A7U3L4H2
      Conserved Domains (1) summary
      smart00442
      Location:69 → 199
      FGF; Acidic and basic fibroblast growth factor family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69686894..69693775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532188.5 → XP_006532251.1  fibroblast growth factor 11 isoform X2

      See identical proteins and their annotated locations for XP_006532251.1

      UniProtKB/TrEMBL
      Q6NXW2
      Conserved Domains (1) summary
      cl00060
      Location:69 → 171
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    2. XM_011248722.3 → XP_011247024.1  fibroblast growth factor 11 isoform X1

      See identical proteins and their annotated locations for XP_011247024.1

      Conserved Domains (1) summary
      smart00442
      Location:69 → 207
      FGF; Acidic and basic fibroblast growth factor family

    3. XM_011248721.3 → XP_011247023.1  fibroblast growth factor 11 isoform X1

      See identical proteins and their annotated locations for XP_011247023.1

      Conserved Domains (1) summary
      smart00442
      Location:69 → 207
      FGF; Acidic and basic fibroblast growth factor family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70378.1 GenPept UniProtKB/Swiss-Prot:P70378

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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