Nme2 NME/NM23 nucleoside diphosphate kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nme2provided by MGI
Official Full Name: NME/NM23 nucleoside diphosphate kinase 2provided by MGI
Primary source: MGI:MGI:97356
See related: Ensembl:ENSMUSG00000020857 AllianceGenome:MGI:97356
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NM23B; NM23-H2; nm23-M2
Summary: Predicted to enable several functions, including G-quadruplex DNA binding activity; anion binding activity; and kinase activity. Predicted to be involved in several processes, including negative regulation of myeloid leukocyte differentiation; nucleotide metabolic process; and protein autophosphorylation. Predicted to act upstream of or within nucleotide metabolic process and phosphorylation. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME1-NME2 (NME1-NME2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 169.6), liver E18 (RPKM 106.9) and 28 other tissues See more
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Genomic context

Location:: 11 D; 11 58.88 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (93840640..93847082, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (93949814..93956256, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients.
Title: Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients.
Histidine kinase NME1 and NME2 are involved in TGF-beta1-induced HSC activation and CCl4-induced liver fibrosis.
Title: Histidine kinase NME1 and NME2 are involved in TGF-β1-induced HSC activation and CCl(4)-induced liver fibrosis.
Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma.
Title: Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma.
Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
Title: Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
Study in transgenic mice reports that the increased levels of Ang-2 are indeed crucial for the development of retinal damage under NDPK-B deficiency and provides evidence that the enhanced O-GlcNAcylation of FoxO1 after NDPK-B depletion is regulating its protein expression and thereby driving the upregulation of Ang-2 in endothelial cells.
Title: O-GlcNAcylation of FoxO1 mediates nucleoside diphosphate kinase B deficiency induced endothelial damage.
Data identify NME2 as one of the two NME isoforms involved in class switch recombination (CSR) in B cells. Its knockdown results in decreased CSR. On the contrary of Nme1; NME2 binds to S regions only after stimulation.
Title: NME proteins regulate class switch recombination.
Results demonstrate that nm23 plays a vital role in decidualization in mice and humans and that nm23 gene expression is hormonally regulated.
Title: nm23 regulates decidualization through the PI3K-Akt-mTOR signaling pathways in mice and humans.
NDPKB-deficient mice are a suitable model for studying mechanisms underlying diabetic retinal vascular damage.
Title: Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina.
These results demonstrate that NME2 associates with PTPsigma to elicit neurite outgrowth inhibition in response to chondroitin sulfate proteoglycans.
Title: NME2 associates with PTPσ to transduce signals from chondroitin sulfate proteoglycans.
NDPKB/SK4 signaling is required for neointima formation in injured carotid arteries.
Title: Nucleoside diphosphate kinase B-activated intermediate conductance potassium channels are critical for neointima formation in mouse carotid arteries.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d10mgh23 (e-PCR)
- UniSTS:120618

RH70845 (e-PCR)
- UniSTS:19132

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables G-quadruplex DNA binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intermediate filament binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in GTP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in UTP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in dTMP biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of myeloid leukocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with intermediate filament	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in myelin sheath	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleoside diphosphate kinase B

Names: NDK B; NDP kinase B; P18; expressed in non-metastatic cells 2 protein; histidine protein kinase NDKB; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside-diphosphate kinase 2

NP_001070997.1

EC 2.7.13.3

EC 2.7.4.6

NP_032731.1

EC 2.7.13.3

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077529.2 → NP_001070997.1 nucleoside diphosphate kinase B

See identical proteins and their annotated locations for NP_001070997.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK216511, AV458476, BC086892

Consensus CDS

CCDS25246.1

UniProtKB/Swiss-Prot

Q01768

UniProtKB/TrEMBL

B0LAA8, Q5NC82

Related

ENSMUSP00000103476.2, ENSMUST00000072566.5

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
NM_008705.5 → NP_032731.1 nucleoside diphosphate kinase B

See identical proteins and their annotated locations for NP_032731.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) and variant 2 encode the same protein.

Source sequence(s)

BC066995, BC086893

Consensus CDS

CCDS25246.1

UniProtKB/Swiss-Prot

Q01768

UniProtKB/TrEMBL

B0LAA8, Q5NC82

Related

ENSMUSP00000021217.5, ENSMUST00000021217.11

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional