Adam9 ADAM metallopeptidase domain 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam9provided by MGI
Official Full Name: ADAM metallopeptidase domain 9provided by MGI
Primary source: MGI:MGI:105376
See related: Ensembl:ENSMUSG00000031555 AllianceGenome:MGI:105376
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MDC9; Mltng; mKIAA0021
Summary: Enables SH3 domain binding activity; metalloendopeptidase activity; and protein kinase C binding activity. Involved in several processes, including cell adhesion mediated by integrin; membrane protein ectodomain proteolysis; and positive regulation of membrane protein ectodomain proteolysis. Located in several cellular components, including cell surface; extracellular space; and plasma membrane. Is intrinsic component of external side of plasma membrane. Is expressed in foregut-midgut junction. Used to study cone-rod dystrophy 9. Human ortholog(s) of this gene implicated in cone-rod dystrophy 9. Orthologous to human ADAM9 (ADAM metallopeptidase domain 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 28.0), lung adult (RPKM 12.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 13.7 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (25439627..25507138, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (24949611..25017040, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-beta1.
Title: ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-β1.
Loss of ADAM9 Leads to Modifications of the Extracellular Matrix Modulating Tumor Growth.
Title: Loss of ADAM9 Leads to Modifications of the Extracellular Matrix Modulating Tumor Growth.
Role of ADAM9 and miR-126 in the development of abdominal aortic aneurysm.
Title: Role of ADAM9 and miR-126 in the development of abdominal aortic aneurysm.
MiR-30e-5p is sponged by Kcnq1ot1 and represses Angiotensin II-induced hypertrophic phenotypes in cardiomyocytes by targeting ADAM9.
Title: MiR-30e-5p is sponged by Kcnq1ot1 and represses Angiotensin II-induced hypertrophic phenotypes in cardiomyocytes by targeting ADAM9.
FMRP Regulates the Nuclear Export of Adam9 and Psen1 mRNAs: Secondary Analysis of an N(6)-Methyladenosine Dataset.
Title: FMRP Regulates the Nuclear Export of Adam9 and Psen1 mRNAs: Secondary Analysis of an N(6)-Methyladenosine Dataset.
ADAM9 is a component of cell-cell junctions. ADAM9 must be expressed by both adjacent cells for cell junction localisation. ADAM9 can self-associate via its ectodomain. The soluble ADAM9 ectodomain inhibits monocyte-endothelial transmigration.
Title: ADAM9 is present at endothelial cell - cell junctions and regulates monocyte - endothelial transmigration.
ADAM9 silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.
Title: RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.
analysis of how ADAM9, 10, and 17 maturation requires processing at a newly identified Proprotein Convertase cleavage site
Title: The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.
ADAM9 is expressed in an inducible fashion on PMN surfaces where it degrades some ECM proteins, and it promotes alveolar-capillary barrier injury during ALI
Title: ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung injury.
Stromal expression of ADAM-9 during melanoma development modulates the expression of TIMP-1 and sTNFR1, which in turn affect tumor cell proliferation and apoptosis.
Title: Stromal fibroblast-specific expression of ADAM-9 modulates proliferation and apoptosis in melanoma cells in vitro and in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adam9 (e-PCR), detects polymorphism
- UniSTS:471065

AU049526 (e-PCR)
- UniSTS:145973

RH136335 (e-PCR)
- UniSTS:210325

Adamts9 (e-PCR), detects polymorphism
- UniSTS:532656

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane protein intracellular domain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in monocyte activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to manganese ion	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 9

Names: a disintegrin and metallopeptidase domain 9 (meltrin gamma); a disintegrin and metalloproteinase domain 9 (meltrin gamma); metalloprotease/disintegrin/cysteine-rich protein 9; myeloma cell metalloproteinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270996.1 → NP_001257925.1 disintegrin and metalloproteinase domain-containing protein 9 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC156553, AK155672, BC052710, BF466217

Consensus CDS

CCDS85516.1

UniProtKB/TrEMBL

A0A140LHU0, Q3UG15

Related

ENSMUSP00000146545.2, ENSMUST00000208247.3

Conserved Domains (7) summary

pfam01391
Location:755 → 810

Collagen; Collagen triple helix repeat (20 copies)

smart00608
Location:500 → 636

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:212 → 404

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:423 → 497

Disintegrin; Disintegrin

pfam01421
Location:212 → 406

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:55 → 160

Pep_M12B_propep; Reprolysin family propeptide

pfam06346
Location:747 → 820

Drf_FH1; Formin Homology Region 1
NM_007404.2 → NP_031430.2 disintegrin and metalloproteinase domain-containing protein 9 isoform 2 precursor

See identical proteins and their annotated locations for NP_031430.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK148174, AK155672, AK161778, BF466217, BY780211, CJ078757

UniProtKB/Swiss-Prot

E9QPP2, Q60618, Q61072, Q61853, Q80U94

UniProtKB/TrEMBL

Q3UG15

Conserved Domains (6) summary

smart00050
Location:423 → 498

DISIN; Homologues of snake disintegrins

smart00608
Location:500 → 636

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:212 → 406

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:44 → 163

Pep_M12B_propep; Reprolysin family propeptide

pfam06346
Location:747 → 802

Drf_FH1; Formin Homology Region 1

pfam07974
Location:650 → 673

EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

25439627..25507138 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508986.5 → XP_006509049.1 disintegrin and metalloproteinase domain-containing protein 9 isoform X1

UniProtKB/TrEMBL

Q3UG15

Conserved Domains (6) summary

smart00608
Location:500 → 636

ACR; ADAM Cysteine-Rich Domain

pfam07974
Location:650 → 673

EGF_2; EGF-like domain

pfam00200
Location:423 → 496

Disintegrin

pfam01421
Location:212 → 406

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:44 → 163

Pep_M12B_propep; Reprolysin family propeptide

pfam06346
Location:747 → 811

Drf_FH1; Formin Homology Region 1
XM_036153724.1 → XP_036009617.1 disintegrin and metalloproteinase domain-containing protein 9 isoform X2

Conserved Domains (4) summary

smart00050
Location:197 → 272

DISIN; Homologues of snake disintegrins

smart00608
Location:274 → 410

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:1 → 180

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam06346
Location:521 → 594

Drf_FH1; Formin Homology Region 1