Cdc14b CDC14 cell division cycle 14B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc14bprovided by MGI
Official Full Name: CDC14 cell division cycle 14Bprovided by MGI
Primary source: MGI:MGI:2441808
See related: Ensembl:ENSMUSG00000033102 AllianceGenome:MGI:2441808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDC14B3; Cdc14B1; 2810432N10Rik; A530086E13Rik
Summary: Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in cilium assembly; microtubule cytoskeleton organization; and regulation of cell cycle process. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleolus. Is expressed in embryo. Orthologous to several human genes including CDC14B (cell division cycle 14B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 6.1), placenta adult (RPKM 2.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B3; 13 33.26 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (64337085..64423670, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (64192545..64274988, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes.
Title: Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes.
Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
Title: Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
Title: Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.
Cdc14B has oncogenic activity in mammals and point to the Ras-MAP kinase pathway as a major effector pathway during oncogenic transformation.
Title: The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway.
Cdc14b is required for efficient DNA damage repair.
Title: Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.
CDC14B is a negative regulator of the 1-to-2-cell transition and of zygotic genome activation in mouse embryogenesis.
Title: Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos.
CDC14B is a negative regulator of meiotic resumption and may regulate meiosis I in mouse oocytes.
Title: CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

RH136507 (e-PCR)
- UniSTS:210489

AU015470 (e-PCR)
- UniSTS:167121

NoName (e-PCR)
- UniSTS:237044

NoName (e-PCR)
- UniSTS:237046

AI849003 (e-PCR)
- UniSTS:165879

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of exit from mitosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity protein phosphatase CDC14B

Names: CDC14 cell division cycle 14 homolog B

NP_001116461.1

EC 3.1.3.16

EC 3.1.3.48

NP_766175.3

EC 3.1.3.16

EC 3.1.3.48

XP_006517282.1

EC 3.1.3.16

EC 3.1.3.48

XP_006517290.1

EC 3.1.3.16

EC 3.1.3.48

XP_006517292.1

EC 3.1.3.16

EC 3.1.3.48

XP_011242817.1

EC 3.1.3.16

EC 3.1.3.48

XP_036013890.1

EC 3.1.3.16

EC 3.1.3.48

XP_036013891.1

EC 3.1.3.16

EC 3.1.3.48

XP_036013892.1

EC 3.1.3.16

EC 3.1.3.48

XP_036013893.1

EC 3.1.3.16

EC 3.1.3.48

XP_036013894.1

EC 3.1.3.16

EC 3.1.3.48

XP_036013895.1

EC 3.1.3.16

EC 3.1.3.48

XP_036013896.1

EC 3.1.3.16

EC 3.1.3.48

XP_036013897.1

EC 3.1.3.16

EC 3.1.3.48

XP_036013898.1

EC 3.1.3.16

EC 3.1.3.48

XP_036013899.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122989.1 → NP_001116461.1 dual specificity protein phosphatase CDC14B isoform 2

See identical proteins and their annotated locations for NP_001116461.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in the use of a novel start codon and a protein (isoform 2) with a shorter, distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK036045, AK041155, BY199064

Consensus CDS

CCDS49292.1

UniProtKB/Swiss-Prot

Q6PFY9

Related

ENSMUSP00000105391.3, ENSMUST00000109769.10

Conserved Domains (2) summary

pfam14671
Location:17 → 151

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:209 → 323

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_172587.3 → NP_766175.3 dual specificity protein phosphatase CDC14B isoform 1

See identical proteins and their annotated locations for NP_766175.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK036045, AK041155, AK044332, CN720173

Consensus CDS

CCDS26598.1

UniProtKB/Swiss-Prot

Q6PFY9, Q80WC4, Q8BLV5

Related

ENSMUSP00000046003.9, ENSMUST00000039318.16

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

64337085..64423670 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158005.1 → XP_036013898.1 dual specificity protein phosphatase CDC14B isoform X11

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_036157997.1 → XP_036013890.1 dual specificity protein phosphatase CDC14B isoform X1

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_036158001.1 → XP_036013894.1 dual specificity protein phosphatase CDC14B isoform X6

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_036158000.1 → XP_036013893.1 dual specificity protein phosphatase CDC14B isoform X5

UniProtKB/TrEMBL

A0A1Y7VJB9

Related

ENSMUSP00000152388.2, ENSMUST00000221634.2

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_036157998.1 → XP_036013891.1 dual specificity protein phosphatase CDC14B isoform X3

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_006517227.4 → XP_006517290.1 dual specificity protein phosphatase CDC14B isoform X10

Conserved Domains (2) summary

cd14499
Location:162 → 335

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

pfam14671
Location:13 → 151

DSPn; Dual specificity protein phosphatase, N-terminal half
XM_036157999.1 → XP_036013892.1 dual specificity protein phosphatase CDC14B isoform X4

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_036158006.1 → XP_036013899.1 dual specificity protein phosphatase CDC14B isoform X13

Conserved Domains (1) summary

cd14499
Location:10 → 183

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
XM_006517229.3 → XP_006517292.1 dual specificity protein phosphatase CDC14B isoform X12

Conserved Domains (1) summary

cd14499
Location:10 → 183

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
XM_006517219.1 → XP_006517282.1 dual specificity protein phosphatase CDC14B isoform X2

Conserved Domains (2) summary

cd14499
Location:162 → 335

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

pfam14671
Location:13 → 151

DSPn; Dual specificity protein phosphatase, N-terminal half
XM_011244515.4 → XP_011242817.1 dual specificity protein phosphatase CDC14B isoform X9

Conserved Domains (2) summary

cd14499
Location:104 → 277

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

pfam14671
Location:1 → 93

DSPn; Dual specificity protein phosphatase, N-terminal half
XM_036158003.1 → XP_036013896.1 dual specificity protein phosphatase CDC14B isoform X7

UniProtKB/Swiss-Prot

Q6PFY9, Q80WC4, Q8BLV5

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_036158004.1 → XP_036013897.1 dual specificity protein phosphatase CDC14B isoform X8

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_036158002.1 → XP_036013895.1 dual specificity protein phosphatase CDC14B isoform X7

UniProtKB/Swiss-Prot

Q6PFY9, Q80WC4, Q8BLV5

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins