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    Rbm18 RNA binding motif protein 18 [ Mus musculus (house mouse) ]

    Gene ID: 67889, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rbm18provided by MGI
    Official Full Name
    RNA binding motif protein 18provided by MGI
    Primary source
    MGI:MGI:1915139
    See related
    Ensembl:ENSMUSG00000026889 AllianceGenome:MGI:1915139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010004P11Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be located in cytosol; intercellular bridge; and nucleoplasm. Is expressed in central nervous system; lung; and sensory organ. Orthologous to human RBM18 (RNA binding motif protein 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 21.2), whole brain E14.5 (RPKM 21.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 24.19 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (36006091..36026716, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (36116079..36136704, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:35904821-35905122 Neighboring gene MORN repeat containing 5 Neighboring gene LIM homeobox protein 6 Neighboring gene mitochondrial ribosome recycling factor Neighboring gene predicted gene, 46735 Neighboring gene STARR-positive B cell enhancer ABC_E5908 Neighboring gene prostaglandin-endoperoxide synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable RNA-binding protein 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159635.1 → NP_001153107.1  probable RNA-binding protein 18 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK035348, BB841783, BE944155, CB183820
      UniProtKB/Swiss-Prot
      Q9CR83
      Conserved Domains (1) summary
      cl17169
      Location:26 → 75
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001355578.1 → NP_001342507.1  probable RNA-binding protein 18 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL773525
      Conserved Domains (1) summary
      cd12355
      Location:26 → 81
      RRM_RBM18; RNA recognition motif in eukaryotic RNA-binding protein 18 and similar proteins

    3. NM_001355579.1 → NP_001342508.1  probable RNA-binding protein 18 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL773525
      Conserved Domains (1) summary
      cd12355
      Location:26 → 80
      RRM_RBM18; RNA recognition motif in eukaryotic RNA-binding protein 18 and similar proteins

    4. NM_001355580.1 → NP_001342509.1  probable RNA-binding protein 18 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL773525
      Conserved Domains (1) summary
      cl17169
      Location:12 → 36
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_026434.4 → NP_080710.1  probable RNA-binding protein 18 isoform 1

      See identical proteins and their annotated locations for NP_080710.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK035348, BE944155, CB183820
      Consensus CDS
      CCDS15969.1
      UniProtKB/Swiss-Prot
      Q8CBD4, Q9CR83
      Related
      ENSMUSP00000028251.4, ENSMUST00000028251.10
      Conserved Domains (2) summary
      cd12355
      Location:26 → 105
      RRM_RBM18; RNA recognition motif in eukaryotic RNA-binding protein 18 and similar proteins
      cl25617
      Location:26 → 189
      LSM_int_assoc; LSM-interacting associated unstructured

    RNA

    1. NR_027515.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1. This results in the transcript being a candidate for nonsense-mediated mRNA decay (NMD), so a protein is not thought to be produced by this transcript.
      Source sequence(s)
      AK035348, BE944155, BY009724, CB183820

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      36006091..36026716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR83.1 GenPept UniProtKB/Swiss-Prot:Q9CR83

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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