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    Dcaf10 DDB1 and CUL4 associated factor 10 [ Mus musculus (house mouse) ]

    Gene ID: 242418, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dcaf10provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 10provided by MGI
    Primary source
    MGI:MGI:2140179
    See related
    Ensembl:ENSMUSG00000035572 AllianceGenome:MGI:2140179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr32
    Summary
    Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and immune system. Orthologous to human DCAF10 (DDB1 and CUL4 associated factor 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 5.1), ovary adult (RPKM 3.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcaf10 in Genome Data Viewer
    Location:
    4 B1; 4 23.87 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45340764..45379732)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45340976..45379732)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45354747-45355003 Neighboring gene predicted gene, 31017 Neighboring gene predicted gene 12585 Neighboring gene STARR-seq mESC enhancer starr_10095 Neighboring gene solute carrier family 25, member 51 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45421840-45422023 Neighboring gene STARR-seq mESC enhancer starr_10098 Neighboring gene predicted gene, 54219 Neighboring gene src homology 2 domain-containing transforming protein B Neighboring gene STARR-positive B cell enhancer ABC_E6172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45477486-45477669 Neighboring gene STARR-seq mESC enhancer starr_10101 Neighboring gene VISTA enhancer mm1668

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. Zhang YL, et al. EMBO J, 2018 Sep 14. PMID 30111536, Free PMC Article
    2. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765
    3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11993, MGC103038

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 10
    Names
    WD repeat domain 32
    WD repeat-containing protein 32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153167.2 → NP_694807.2  DDB1- and CUL4-associated factor 10

      See identical proteins and their annotated locations for NP_694807.2

      Status: VALIDATED

      Source sequence(s)
      AK083428, AL772376, BX526643, BY732400, CN533345
      Consensus CDS
      CCDS38754.1
      UniProtKB/Swiss-Prot
      A2AKB9, A2AKV8, Q3TNI7, Q5U4G6, Q8BHQ2, Q8BHS1, Q8BHX4, Q8K3A5
      Related
      ENSMUSP00000117082.2, ENSMUST00000155551.8
      Conserved Domains (4) summary
      smart00320
      Location:524 → 562
      WD40; WD40 repeats
      COG2319
      Location:178 → 326
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:179 → 214
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:171 → 326
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      45340764..45379732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537912.5 → XP_006537975.1  DDB1- and CUL4-associated factor 10 isoform X1

      Conserved Domains (1) summary
      smart00320
      Location:458 → 496
      WD40; WD40 repeats
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AKB9.1 GenPept UniProtKB/Swiss-Prot:A2AKB9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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