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    Grb10 growth factor receptor bound protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 14783, updated on 19-Jul-2021

    Summary

    Official Symbol
    Grb10provided by MGI
    Official Full Name
    growth factor receptor bound protein 10provided by MGI
    Primary source
    MGI:MGI:103232
    See related
    Ensembl:ENSMUSG00000020176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Meg1; AI325020; mKIAA0207; 5730571D09Rik
    Expression
    Biased expression in limb E14.5 (RPKM 223.2), liver E18 (RPKM 212.5) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Grb10 in Genome Data Viewer
    Location:
    11 A1; 11 7.15 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11880499..11987428, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11930499..12037428, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (11830502..11937423, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dopa decarboxylase Neighboring gene RIKEN cDNA 1700042O10 gene Neighboring gene predicted gene, 25058 Neighboring gene VISTA enhancer mm154 Neighboring gene uncharacterized LOC102631979 Neighboring gene VISTA enhancer mm178 Neighboring gene predicted gene, 30423 Neighboring gene predicted gene, 24036

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables insulin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotyrosine residue binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor complex adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within_negative_effect ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_negative_effect gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glycogen biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within vascular associated smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    growth factor receptor-bound protein 10
    Names
    GRB10 adapter protein
    maternally expressed gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177629.1NP_001171100.1  growth factor receptor-bound protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001171100.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' non-coding exon, and is missing in-frame coding exons compared to variant 3. This results in a shorter isoform (2) lacking an internal protein segment compared to isoform 3.
      Source sequence(s)
      AL663087, BC053842, BY122902, CK635114
      Consensus CDS
      CCDS48754.1
      UniProtKB/Swiss-Prot
      Q60760
      Related
      ENSMUSP00000105281.2, ENSMUST00000109654.8
      Conserved Domains (4) summary
      cd10415
      Location:434541
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:234356
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:114205
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:373414
      BPS; BPS (Between PH and SH2)
    2. NM_001370603.1NP_001357532.1  growth factor receptor-bound protein 10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes isoform (3).
      Source sequence(s)
      AL645803, AL663087
      Conserved Domains (4) summary
      cd10415
      Location:514621
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:314436
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:453494
      BPS; BPS (Between PH and SH2)
      cd16141
      Location:197285
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    3. NM_010345.4NP_034475.2  growth factor receptor-bound protein 10 isoform 1

      See identical proteins and their annotated locations for NP_034475.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) includes an alternate internal exon, compared to variant 3. It encodes isoform 1 which is shorter, compared to isoform 3.
      Source sequence(s)
      BC053842, CK635114, FJ425892
      Consensus CDS
      CCDS24440.1
      UniProtKB/Swiss-Prot
      Q60760
      Related
      ENSMUSP00000091011.6, ENSMUST00000093321.12
      Conserved Domains (5) summary
      cd01787
      Location:170251
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:489596
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:289411
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:294402
      PH; PH domain
      pfam08947
      Location:428469
      BPS; BPS (Between PH and SH2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      11880499..11987428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243664.2XP_011241966.1  growth factor receptor-bound protein 10 isoform X1

      See identical proteins and their annotated locations for XP_011241966.1

      UniProtKB/Swiss-Prot
      Q60760
      Conserved Domains (4) summary
      cd10415
      Location:434541
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:234356
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:114205
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:373414
      BPS; BPS (Between PH and SH2)
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