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    Zfp663 zinc finger protein 663 [ Mus musculus (house mouse) ]

    Gene ID: 381405, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp663provided by MGI
    Official Full Name
    zinc finger protein 663provided by MGI
    Primary source
    MGI:MGI:2685854
    See related
    Ensembl:ENSMUSG00000056824 AllianceGenome:MGI:2685854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1008
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; ganglia; glans of male genital tubercle; retina; and skeletal musculature. Orthologous to human ZNF663P (zinc finger protein 663, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E14 (RPKM 1.2), whole brain E14.5 (RPKM 1.1) and 6 other tissues See more
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    Genomic context

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    Location:
    2 H3; 2 85.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165193217..165210656, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165351297..165368736, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member C2 Neighboring gene engulfment and cell motility 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165147221-165147404 Neighboring gene STARR-positive B cell enhancer ABC_E418 Neighboring gene predicted gene, 29831 Neighboring gene STARR-seq mESC enhancer starr_06348 Neighboring gene zinc finger protein 334 Neighboring gene osteoclast stimulatory transmembrane protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC86131

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 663

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005425.2 → NP_001005425.1  zinc finger protein 663 isoform a

      See identical proteins and their annotated locations for NP_001005425.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AL591064, AL591430
      Consensus CDS
      CCDS17078.1
      UniProtKB/TrEMBL
      Q6NXM6
      Related
      ENSMUSP00000099374.2, ENSMUST00000103085.8
      Conserved Domains (5) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:456 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:474 → 494
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:528 → 550
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:598 → 623
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001379474.1 → NP_001366403.1  zinc finger protein 663 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AL591064, AL591430
      UniProtKB/TrEMBL
      Q6NXM6
      Conserved Domains (5) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:456 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:474 → 494
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:528 → 550
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:598 → 623
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001379475.1 → NP_001366404.1  zinc finger protein 663 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AL591064, AL591430
      UniProtKB/TrEMBL
      Q6NXM6
      Related
      ENSMUSP00000072813.8, ENSMUST00000073062.14
      Conserved Domains (5) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:456 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:474 → 494
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:528 → 550
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:598 → 623
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001379476.1 → NP_001366405.1  zinc finger protein 663 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL591064, AL591430
      Conserved Domains (5) summary
      COG5048
      Location:420 → 495
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:492 → 514
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:562 → 587
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      165193217..165210656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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