Gabpa GA repeat binding protein, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gabpaprovided by MGI
Official Full Name: GA repeat binding protein, alphaprovided by MGI
Primary source: MGI:MGI:95610
See related: Ensembl:ENSMUSG00000008976 AllianceGenome:MGI:95610
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GABPalpha
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within blastocyst formation; negative regulation of megakaryocyte differentiation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human GABPA (GA binding protein transcription factor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 12.4), limb E14.5 (RPKM 10.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 46.92 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (84631795..84660671)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (84834891..84863783)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of GABPalpha impairs T-cell homeostatic survival, proliferation, and antigen-induced responses in vivo.
Title: Ets transcription factor GABP controls T cell homeostasis and immunity.
GABPalpha Binding to Overlapping ETS and CRE DNA Motifs Is Enhanced by CREB1
Title: GABPα Binding to Overlapping ETS and CRE DNA Motifs Is Enhanced by CREB1: Custom DNA Microarrays.
conditionally deleted Gabpa, the DNA-binding component of this transcription factor complex, from embryonic fibroblasts to examine the role of Gabp in mitochondrial biogenesis, function, and gene expression
Title: GABP transcription factor (nuclear respiratory factor 2) is required for mitochondrial biogenesis.
Loss of Gabpalpha prevented development of CML, although mice continued to generate BCR-ABL-expressing Gabpalpha-null cells for months that were serially transplantable and contributed to all lineages in secondary recipients.
Title: GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2.
NRF-2 and NRF-1 operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.
Title: Nuclear respiratory factor 2 regulates the expression of the same NMDA receptor subunit genes as NRF-1: both factors act by a concurrent and parallel mechanism to couple energy metabolism and synaptic transmission.
Through genome-wide mapping of GABPalpha binding and transcriptomic analysis of GABPalpha-deficient HSCs, we identified Zfx and Etv6 transcription factors and prosurvival Bcl-2 family members including Bcl-2, Bcl-X(L), and Mcl-1 as direct GABP target genes.
Title: GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells.
Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1.
Title: GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expression.
functional relevance of the -119 GABP-binding site in the Robo4 promoter in vivo
Title: A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo.
Il7ra promoter acetylation and activity was dependent on the reciprocal binding of GABPalpha and Gfi-1. Data provide a biochemical mechanism for the generation of stable IL-7Ralpha(high) and IL-7Ralpha(low) states in virus-specific effector CD8 T cells.
Title: Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1.
Ther is a direct structural link between GABP and a central component of the transcriptional machinery.
Title: Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (5) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gabpa (e-PCR), detects polymorphism
- UniSTS:259081

Gabpa (e-PCR), detects polymorphism
- UniSTS:546776

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of megakaryocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: GA-binding protein alpha chain

Names: GA-binding protein alpha-subunit; GABP subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416806.1 → NP_001403735.1 GA-binding protein alpha chain isoform 1

Status: VALIDATED

Source sequence(s)

AC164162

UniProtKB/Swiss-Prot

Q00422, Q7TT22
NM_001416807.1 → NP_001403736.1 GA-binding protein alpha chain isoform 1

Status: VALIDATED

Source sequence(s)

AC164162

UniProtKB/Swiss-Prot

Q00422, Q7TT22

Related

ENSMUSP00000109822.2, ENSMUST00000114184.8
NM_001416809.1 → NP_001403738.1 GA-binding protein alpha chain isoform 2

Status: VALIDATED

Source sequence(s)

AC164162
NM_001416810.1 → NP_001403739.1 GA-binding protein alpha chain isoform 3

Status: VALIDATED

Source sequence(s)

AC164162
NM_001416811.1 → NP_001403740.1 GA-binding protein alpha chain isoform 3

Status: VALIDATED

Source sequence(s)

AC164162
NM_001416812.1 → NP_001403741.1 GA-binding protein alpha chain isoform 4

Status: VALIDATED

Source sequence(s)

AC164162
NM_001416813.1 → NP_001403742.1 GA-binding protein alpha chain isoform 4

Status: VALIDATED

Source sequence(s)

AC164162
NM_008065.3 → NP_032091.2 GA-binding protein alpha chain isoform 1

See identical proteins and their annotated locations for NP_032091.2

Status: VALIDATED

Source sequence(s)

AC164162

Consensus CDS

CCDS28284.1

UniProtKB/Swiss-Prot

Q00422, Q7TT22

UniProtKB/TrEMBL

Q6HAA1

Related

ENSMUSP00000009120.8, ENSMUST00000009120.8

Conserved Domains (3) summary

cd08534
Location:168 → 254

SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain

smart00413
Location:319 → 403

ETS; erythroblast transformation specific domain

pfam11620
Location:40 → 119

GABP-alpha; GA-binding protein alpha chain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

84631795..84660671

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522906.3 → XP_006522969.1 GA-binding protein alpha chain isoform X1

See identical proteins and their annotated locations for XP_006522969.1

UniProtKB/TrEMBL

Q6HAA1

Conserved Domains (3) summary

cd08534
Location:168 → 254

SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain

smart00413
Location:321 → 405

ETS; erythroblast transformation specific domain

pfam11620
Location:40 → 119

GABP-alpha; GA-binding protein alpha chain
XM_006522905.5 → XP_006522968.1 GA-binding protein alpha chain isoform X1

See identical proteins and their annotated locations for XP_006522968.1

UniProtKB/TrEMBL

Q6HAA1

Conserved Domains (3) summary

cd08534
Location:168 → 254

SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain

smart00413
Location:321 → 405

ETS; erythroblast transformation specific domain

pfam11620
Location:40 → 119

GABP-alpha; GA-binding protein alpha chain
XM_017316875.3 → XP_017172364.1 GA-binding protein alpha chain isoform X3

UniProtKB/TrEMBL

Q6HAA1

Conserved Domains (3) summary

smart00413
Location:256 → 340

ETS; erythroblast transformation specific domain

pfam11620
Location:40 → 119

GABP-alpha; GA-binding protein alpha chain

cl15755
Location:168 → 192

SAM_superfamily; SAM (Sterile alpha motif )