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    Cramp1 cramped chromatin regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 57354, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cramp1provided by MGI
    Official Full Name
    cramped chromatin regulator 1provided by MGI
    Primary source
    MGI:MGI:1930190
    See related
    Ensembl:ENSMUSG00000038002 AllianceGenome:MGI:1930190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tce4; Cramp1l; mKIAA1426; 5830477H08Rik
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in pattern specification process. Predicted to be active in nucleus. Orthologous to human CRAMP1 (cramped chromatin regulator homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.4), limb E14.5 (RPKM 12.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25180200..25234819, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24961226..25015840, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E7499 Neighboring gene STARR-positive B cell enhancer ABC_E1500 Neighboring gene Jupiter microtubule associated homolog 2 Neighboring gene STARR-positive B cell enhancer ABC_E396 Neighboring gene intraflagellar transport 140 Neighboring gene STARR-positive B cell enhancer ABC_E11631 Neighboring gene transmembrane protein 204 Neighboring gene telomere maintenance 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers. Mendez-Frausto G, et al. Exp Mol Pathol, 2021 Dec. PMID 34592200
    2. Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Kargul GJ, et al. Genome Res, 2000 Jul. PMID 10899141, Free PMC Article
    3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers.
      Title: Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1426

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein cramped-like
    Names
    Crm, cramped-like
    cramped chromatin regulator homolog 1
    hematological and neurological expressed 1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403565.1 → NP_001390494.1  protein cramped-like

      Status: VALIDATED

      Source sequence(s)
      AC154229
      UniProtKB/Swiss-Prot
      E9QNA8, Q6PG95, Q6ZPR3
      Related
      ENSMUSP00000156906.2, ENSMUST00000233774.2

    2. NM_020608.3 → NP_065633.2  protein cramped-like

      See identical proteins and their annotated locations for NP_065633.2

      Status: VALIDATED

      Source sequence(s)
      AK030991, AK089393, AK147411, BE946250
      Consensus CDS
      CCDS50030.1
      UniProtKB/Swiss-Prot
      E9QNA8, Q6PG95, Q6ZPR3
      Related
      ENSMUSP00000073060.7, ENSMUST00000073337.8
      Conserved Domains (2) summary
      PHA03309
      Location:441 → 619
      PHA03309; transcriptional regulator ICP4; Provisional
      pfam04642
      Location:125 → 205
      DUF601; Protein of unknown function, DUF601

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25180200..25234819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524703.5 → XP_006524766.1  protein cramped-like isoform X1

      See identical proteins and their annotated locations for XP_006524766.1

      UniProtKB/Swiss-Prot
      E9QNA8, Q6PG95, Q6ZPR3
      Conserved Domains (2) summary
      PHA03309
      Location:441 → 619
      PHA03309; transcriptional regulator ICP4; Provisional
      pfam04642
      Location:125 → 205
      DUF601; Protein of unknown function, DUF601

    2. XM_017317589.3 → XP_017173078.1  protein cramped-like isoform X1

      UniProtKB/Swiss-Prot
      E9QNA8, Q6PG95, Q6ZPR3
      Conserved Domains (2) summary
      PHA03309
      Location:441 → 619
      PHA03309; transcriptional regulator ICP4; Provisional
      pfam04642
      Location:125 → 205
      DUF601; Protein of unknown function, DUF601

    3. XM_006524699.4 → XP_006524762.1  protein cramped-like isoform X2

      Conserved Domains (2) summary
      PHA03309
      Location:491 → 669
      PHA03309; transcriptional regulator ICP4; Provisional
      pfam04642
      Location:175 → 255
      DUF601; Protein of unknown function, DUF601

    4. XM_011246545.3 → XP_011244847.1  protein cramped-like isoform X3

      Conserved Domains (2) summary
      PHA03309
      Location:441 → 619
      PHA03309; transcriptional regulator ICP4; Provisional
      pfam04642
      Location:125 → 205
      DUF601; Protein of unknown function, DUF601
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PG95.3 GenPept UniProtKB/Swiss-Prot:Q6PG95

    Gene LinkOut

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