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    Tcp10c t-complex protein 10c [ Mus musculus (house mouse) ]

    Gene ID: 100041352, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tcp10cprovided by MGI
    Official Full Name
    t-complex protein 10cprovided by MGI
    Primary source
    MGI:MGI:98543
    See related
    Ensembl:ENSMUSG00000052469 AllianceGenome:MGI:98543
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm9880; T66C-a; Tcp-10c; D17Leh66C; D17Leh66ca
    Summary
    Predicted to enable several functions, including identical protein binding activity; protein self-association; and transcription corepressor activity. Predicted to be active in centriole and nucleus. Orthologous to several human genes including TCP10L (t-complex 10 like) and TCP10L2 (t-complex 10 like 2, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 144.4) See more
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    Genomic context

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    See Tcp10c in Genome Data Viewer
    Location:
    17 8.86 cM; 17 A1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13574834..13597485)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (13354572..13377223)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 31, D17Leh66c region Neighboring gene predicted gene, 36537 Neighboring gene tubulin tyrosine ligase-like family, member 2 pseudogene Neighboring gene predicted gene, 25730

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An unstable family of large DNA elements in the center of the mouse t complex. Schimenti J, et al. J Mol Biol, 1987 Apr 20. PMID 2821263
    2. Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes. Röhme D, et al. Cell, 1984 Mar. PMID 6697397
    3. Sequence of the t complex Tcp-10at gene and examination of the Tcp-10t gene family. Davies PO, et al. Mamm Genome, 1991. PMID 1794052
    4. A candidate gene family for the mouse t complex responder (Tcr) locus responsible for haploid effects on sperm function. Schimenti J, et al. Cell, 1988 Oct 7. PMID 3167978
    5. Molecular cloning and genetic mapping of the t complex responder candidate gene family. Bullard DC, et al. Genetics, 1990 Apr. PMID 2323558, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    t-complex protein 10c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167578.1 → NP_001161050.1  t-complex protein 10c

      Status: VALIDATED

      Source sequence(s)
      AC166110, AK076614, CJ046593
      Consensus CDS
      CCDS49953.1
      UniProtKB/TrEMBL
      E9Q046, Q8C641
      Related
      ENSMUSP00000095015.4, ENSMUST00000097403.4
      Conserved Domains (2) summary
      cl21524
      Location:17 → 111
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional
      pfam07202
      Location:308 → 480
      Tcp10_C; T-complex protein 10 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      13574834..13597485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523280.3 → XP_006523343.1  t-complex protein 10c isoform X4

      UniProtKB/TrEMBL
      Q8C641
      Conserved Domains (1) summary
      pfam07202
      Location:341 → 514
      Tcp10_C; T-complex protein 10 C-terminus

    2. XM_006523277.3 → XP_006523340.1  t-complex protein 10c isoform X1

      Conserved Domains (1) summary
      pfam07202
      Location:401 → 574
      Tcp10_C; T-complex protein 10 C-terminus

    3. XM_006523278.4 → XP_006523341.1  t-complex protein 10c isoform X2

      UniProtKB/TrEMBL
      Q8C641
      Conserved Domains (2) summary
      cl21524
      Location:77 → 171
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional
      pfam07202
      Location:368 → 541
      Tcp10_C; T-complex protein 10 C-terminus

    4. XM_006523279.3 → XP_006523342.1  t-complex protein 10c isoform X3

      UniProtKB/TrEMBL
      B2RUN1
      Conserved Domains (1) summary
      pfam07202
      Location:348 → 521
      Tcp10_C; T-complex protein 10 C-terminus

    5. XM_006523281.4 → XP_006523344.1  t-complex protein 10c isoform X5

      UniProtKB/TrEMBL
      Q8C641
      Conserved Domains (2) summary
      cl21524
      Location:77 → 171
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional
      pfam07202
      Location:315 → 488
      Tcp10_C; T-complex protein 10 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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