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    Trim34a tripartite motif-containing 34A [ Mus musculus (house mouse) ]

    Gene ID: 94094, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Trim34aprovided by MGI
    Official Full Name
    tripartite motif-containing 34Aprovided by MGI
    Primary source
    MGI:MGI:2137359
    See related
    Ensembl:ENSMUSG00000056144 AllianceGenome:MGI:2137359
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trim34; Trim34-1
    Summary
    Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and regulation of viral entry into host cell. Predicted to act upstream of or within defense response to virus. Predicted to be active in cytosol and nucleoplasm. Is expressed in testis and ureter. Orthologous to several human genes including TRIM34 (tripartite motif containing 34). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 7.3), spleen adult (RPKM 7.0) and 28 other tissues See more
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    Genomic context

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    See Trim34a in Genome Data Viewer
    Location:
    7 E3; 7 55.69 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103893657..103911446)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104244448..104262244)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 6, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_19731 Neighboring gene tripartite motif-containing 6 Neighboring gene predicted gene 8667 Neighboring gene STARR-positive B cell enhancer ABC_E6578 Neighboring gene STARR-seq mESC enhancer starr_19732 Neighboring gene predicted gene, 24846 Neighboring gene tripartite motif-containing 5 Neighboring gene predicted gene, 57517

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination. Wang X, et al. J Biol Chem, 2022 Mar. PMID 35065966, Free PMC Article
    2. An expanded clade of rodent Trim5 genes. Tareen SU, et al. Virology, 2009 Mar 15. PMID 19147168, Free PMC Article
    3. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article
    4. The tripartite motif family identifies cell compartments. Reymond A, et al. EMBO J, 2001 May 1. PMID 11331580, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM34A
    Names
    tripartite motif protein 34
    tripartite motif-containing 34
    tripartite motif-containing protein 34
    tripartite motif-containing protein 34A
    NP_001344608.1
    NP_001408613.1
    NP_109609.2
    XP_006508432.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357679.2 → NP_001344608.1  E3 ubiquitin-protein ligase TRIM34A

      Status: VALIDATED

      Source sequence(s)
      AC123830
      Consensus CDS
      CCDS52342.1
      UniProtKB/Swiss-Prot
      E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6
      UniProtKB/TrEMBL
      Q3TAH7
      Related
      ENSMUSP00000055058.6, ENSMUST00000060315.12
      Conserved Domains (4) summary
      TIGR02168
      Location:134 → 241
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15825
      Location:299 → 482
      SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
      cd19761
      Location:94 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:14 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001421684.1 → NP_001408613.1  E3 ubiquitin-protein ligase TRIM34A

      Status: VALIDATED

      Source sequence(s)
      AC123830
      UniProtKB/Swiss-Prot
      E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6

    3. NM_030684.4 → NP_109609.2  E3 ubiquitin-protein ligase TRIM34A

      See identical proteins and their annotated locations for NP_109609.2

      Status: VALIDATED

      Source sequence(s)
      AC123830
      Consensus CDS
      CCDS52342.1
      UniProtKB/Swiss-Prot
      E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6
      UniProtKB/TrEMBL
      Q3TAH7
      Related
      ENSMUSP00000102462.3, ENSMUST00000106849.9
      Conserved Domains (4) summary
      TIGR02168
      Location:134 → 241
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15825
      Location:299 → 482
      SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
      cd19761
      Location:94 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:14 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. NR_185321.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123830

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      103893657..103911446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508369.4 → XP_006508432.1  E3 ubiquitin-protein ligase TRIM34A isoform X1

      See identical proteins and their annotated locations for XP_006508432.1

      UniProtKB/Swiss-Prot
      E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6
      UniProtKB/TrEMBL
      Q3TAH7
      Conserved Domains (4) summary
      TIGR02168
      Location:134 → 241
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15825
      Location:299 → 482
      SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
      cd19761
      Location:94 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:14 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. XR_003946603.2 RNA Sequence

    2. XR_004934226.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PP6.3 GenPept UniProtKB/Swiss-Prot:Q99PP6

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