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    Ldhd lactate dehydrogenase D [ Mus musculus (house mouse) ]

    Gene ID: 52815, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ldhdprovided by MGI
    Official Full Name
    lactate dehydrogenase Dprovided by MGI
    Primary source
    MGI:MGI:106428
    See related
    Ensembl:ENSMUSG00000031958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DLD; D8Bwg1320e; 4733401P21Rik
    Expression
    Biased expression in genital fat pad adult (RPKM 169.0), kidney adult (RPKM 153.8) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Ldhd in Genome Data Viewer
    Location:
    8 E1; 8 57.98 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112352243..112361363, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111625611..111630336, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (114150171..114154222, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24793 Neighboring gene WD repeat domain 59 Neighboring gene zinc and ring finger 1 Neighboring gene zinc finger protein 1 Neighboring gene microRNA 7076 Neighboring gene chymotrypsinogen B1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-lactate dehydrogenase (cytochrome) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables D-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables D-lactate dehydrogenase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in lactate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lactate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    probable D-lactate dehydrogenase, mitochondrial
    NP_081846.3
    XP_036010057.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027570.4NP_081846.3  probable D-lactate dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_081846.3

      Status: VALIDATED

      Source sequence(s)
      AC122364
      Consensus CDS
      CCDS22677.1
      UniProtKB/Swiss-Prot
      Q7TNG8
      Related
      ENSMUSP00000068086.4, ENSMUST00000070004.4
      Conserved Domains (3) summary
      COG0277
      Location:34484
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:66202
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:243483
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      112352243..112361363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154164.1XP_036010057.1  probable D-lactate dehydrogenase, mitochondrial isoform X1

      Conserved Domains (1) summary
      PLN02805
      Location:117583
      PLN02805; D-lactate dehydrogenase [cytochrome]
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