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    Art1 ADP-ribosyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 11870, updated on 23-Mar-2024

    Summary

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    Official Symbol
    Art1provided by MGI
    Official Full Name
    ADP-ribosyltransferase 1provided by MGI
    Primary source
    MGI:MGI:107511
    See related
    Ensembl:ENSMUSG00000030996 AllianceGenome:MGI:107511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADPRT; ARTC1; Yac-1
    Summary
    Enables NAD+ ADP-ribosyltransferase activity. Acts upstream of or within protein ADP-ribosylation. Located in cell surface. Is anchored component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human ART1 (ADP-ribosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 63.2), mammary gland adult (RPKM 11.5) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Art1 in Genome Data Viewer
    Location:
    7 E2; 7 54.71 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101750913..101771410)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102101706..102122062)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interleukin 18 binding protein Neighboring gene ring finger protein 121 Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 10 Neighboring gene STARR-seq mESC enhancer starr_19704 Neighboring gene nucleoporin 98 Neighboring gene STARR-seq mESC enhancer starr_19705 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:109358847-109359078 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ras homolog family member G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo. Xu JX, et al. Mol Med Rep, 2017 Mar. PMID 28138708, Free PMC Article
    2. ART1 silencing enhances apoptosis of mouse CT26 cells via the PI3K/Akt/NF-κB pathway. Xiao M, et al. Cell Physiol Biochem, 2013. PMID 24335275
    3. Identification of regulatory domains in ADP-ribosyltransferase-1 that determine transferase and NAD glycohydrolase activities. Bourgeois C, et al. J Biol Chem, 2003 Jul 18. PMID 12721285
    4. Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in Colorectal Cancer via the PI3K/AKT/HIF1α Pathway. Long WB, et al. Curr Med Sci, 2022 Aug. PMID 35798928
    5. Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme. Leutert M, et al. Cell Rep, 2018 Aug 14. PMID 30110646

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells.
      Title: ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells.
    2. High Norepinephrine State Induces Growth of Colorectal Cancer Cells via ADP-Ribosyltransferase 1 in Type 2 Diabetes Mellitus.
      Title: High Norepinephrine State Induces Growth of Colorectal Cancer Cells via ADP-Ribosyltransferase 1 in Type 2 Diabetes Mellitus.
    3. Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in Colorectal Cancer via the PI3K/AKT/HIF1alpha Pathway.
      Title: Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in Colorectal Cancer via the PI3K/AKT/HIF1α Pathway.
    4. Proteomic characterization of the heart and skeletal muscle reveals widespread arginine ADP-ribosylation by the ARTC1 ectoenzyme with hemopexin being its target protein.
      Title: Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme.
    5. The results demonstrated that ART1 gene silencing inhibited the growth of the spleen transplanted tumor and its ability to spread to the liver via metastasis.
      Title: Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo.
    6. data suggest that ART1 promoted the expression of HIF-1alpha via the Akt pathway in tumor cells.
      Title: Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.
    7. the apoptosis rate in the ART1-cDNA CT26 cells treated with PARP-1 inhibitor 5-aminoisoquinoline (5-AIQ) and cisplatin increased, when compared with the ART1-cDNA CT26 cells treated with cisplatin only or the untreated ART1-cDNA CT26 cells.
      Title: Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells.
    8. ART1 knockdown reduced survival rate correlated with reduced levels of phos-Akt(Thr308) and phos-IkappaBalpha and reduced NF-kappaB p65 nuclear translocation.
      Title: ART1 silencing enhances apoptosis of mouse CT26 cells via the PI3K/Akt/NF-κB pathway.
    9. Successive amino- or carboxyl-terminal truncations of ART1, an arginine-specific transferase, identified regions that regulated transferase and NAD glycohydrolase activities.
      Title: Identification of regulatory domains in ADP-ribosyltransferase-1 that determine transferase and NAD glycohydrolase activities.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
    Names
    ADP-ribosyltransferase C2 and C3 toxin-like 1
    mono(ADP-ribosyl)transferase 1
    NP_001398911.1
    NP_033840.2
    XP_011239959.1
    XP_036008500.1
    XP_036008501.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411982.1 → NP_001398911.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132297
      UniProtKB/TrEMBL
      Q9D7F1
      Related
      ENSMUSP00000148204.2, ENSMUST00000210211.2

    2. NM_009710.5 → NP_033840.2  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033840.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC132297
      Consensus CDS
      CCDS21526.1
      UniProtKB/Swiss-Prot
      P70688, Q60935
      UniProtKB/TrEMBL
      Q545U9
      Related
      ENSMUSP00000033300.3, ENSMUST00000033300.4
      Conserved Domains (1) summary
      pfam01129
      Location:39 → 269
      ART; NAD:arginine ADP-ribosyltransferase

    RNA

    1. NR_177992.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC118592, AC132297

    2. NR_177993.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132297

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101750913..101771410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152608.1 → XP_036008501.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X2

      Conserved Domains (1) summary
      cl00173
      Location:39 → 179
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    2. XM_011241657.3 → XP_011239959.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_011239959.1

      UniProtKB/Swiss-Prot
      P70688, Q60935
      UniProtKB/TrEMBL
      Q545U9
      Conserved Domains (1) summary
      pfam01129
      Location:39 → 269
      ART; NAD:arginine ADP-ribosyltransferase

    3. XM_036152607.1 → XP_036008500.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      P70688, Q60935
      UniProtKB/TrEMBL
      Q545U9
      Conserved Domains (1) summary
      pfam01129
      Location:39 → 269
      ART; NAD:arginine ADP-ribosyltransferase

    RNA

    1. XR_869649.3 RNA Sequence

    2. XR_004933998.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60935.1 GenPept UniProtKB/Swiss-Prot:Q60935

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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