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    Epb41 erythrocyte membrane protein band 4.1 [ Mus musculus (house mouse) ]

    Gene ID: 269587, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Epb41provided by MGI
    Official Full Name
    erythrocyte membrane protein band 4.1provided by MGI
    Primary source
    MGI:MGI:95401
    See related
    Ensembl:ENSMUSG00000028906 AllianceGenome:MGI:95401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4.1R; Elp1; Elp-1; Epb4.1; mKIAA4056; D4Ertd442e
    Summary
    Predicted to enable several functions, including 1-phosphatidylinositol binding activity; cytoskeletal protein binding activity; and protein C-terminus binding activity. Involved in regulation of calcium ion transport and regulation of intestinal absorption. Acts upstream of or within positive regulation of protein binding activity. Located in basolateral plasma membrane and cortical cytoskeleton. Is expressed in several structures, including alimentary system; brain; connective tissue; eye; and genitourinary system. Used to study hereditary elliptocytosis. Orthologous to human EPB41 (erythrocyte membrane protein band 4.1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 23.5), liver E14 (RPKM 23.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.3; 4 64.54 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131650724..131802824, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (131923413..132075346, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene serine and arginine-rich splicing factor 4 Neighboring gene predicted gene 12992 Neighboring gene phosphatidylinositol 3-kinase, catalytic, beta polypeptide pseudogene Neighboring gene transmembrane protein 200B Neighboring gene VISTA enhancer mm1387 Neighboring gene STARR-positive B cell enhancer ABC_E4674 Neighboring gene predicted gene, 36157 Neighboring gene VISTA enhancer mm80 Neighboring gene STARR-positive B cell enhancer ABC_E3518 Neighboring gene STARR-seq mESC enhancer starr_11553 Neighboring gene STARR-seq mESC enhancer starr_11554 Neighboring gene opioid receptor, delta 1 Neighboring gene nuclear encoded tRNA alanine 3 (anticodon CGC) Neighboring gene predicted gene 13215

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein 4.1R affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid. Li B, et al. Exp Cell Res, 2021 Feb 15. PMID 33385415
    2. Protein 4.1R negatively regulates P815 cells proliferation by inhibiting C-Kit-mediated signal transduction. Ding C, et al. Exp Cell Res, 2021 Jan 15. PMID 33271128
    3. Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-κB pathway. Liang T, et al. Immunology, 2020 Dec. PMID 32852059, Free PMC Article
    4. Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells. Zhao Q, et al. Med Sci Monit, 2020 Mar 11. PMID 32157074, Free PMC Article
    5. Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells. Draberova L, et al. Front Immunol, 2019. PMID 31993060, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The protein 4.1R downregulates VEGFA in M2 macrophages to inhibit colon cancer metastasis.
      Title: The protein 4.1R downregulates VEGFA in M2 macrophages to inhibit colon cancer metastasis.
    2. Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation.
      Title: Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation.
    3. Protein 4.1R affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid.
      Title: Protein 4.1R affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid.
    4. Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-kappaB pathway.
      Title: Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-κB pathway.
    5. Protein 4.1R negatively regulates P815 cells proliferation by inhibiting C-Kit-mediated signal transduction.
      Title: Protein 4.1R negatively regulates P815 cells proliferation by inhibiting C-Kit-mediated signal transduction.
    6. Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells.
      Title: Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells.
    7. Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcepsilonRI Signaling and Chemotaxis in Mast Cells.
      Title: Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells.
    8. The role of 4.1R in the regulation of EGFR signaling in keratinocytes.
      Title: Cytoskeleton protein 4.1R suppresses murine keratinocyte cell hyperproliferation via activating the Akt/ERK pathway in an EGFR-dependent manner.
    9. These data enabled the identification of a negative regulation function for 4.1R in CD8(+) T cells by a direct association between 4.1R and LAT, possibly through inhibiting phosphorylation of LAT and then modulating intracellular signal transduction.
      Title: Protein 4.1R negatively regulates CD8(+) T-cell activation by modulating phosphorylation of linker for activation of T cells.
    10. Formation of an erythroid-specific, protein 4.1R-dependent membrane skeleton is an important feature not only of definitive, but also of primitive, erythropoiesis in mammals.
      Title: Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4056

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables spectrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of intestinal absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein 4.1
    Names
    P4.1
    Protein 4.1R
    band 4.1
    erythrocyte protein band 4.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128606.1 → NP_001122078.1  protein 4.1 isoform 2

      See identical proteins and their annotated locations for NP_001122078.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple in-frame exons and uses a different 5' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AK220462, CA324069
      Consensus CDS
      CCDS51317.1
      UniProtKB/TrEMBL
      A2A842
      Related
      ENSMUSP00000081274.4, ENSMUST00000084253.10
      Conserved Domains (7) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:297 → 402
      FERM_M; FERM central domain
      pfam04382
      Location:609 → 653
      SAB; SAB domain
      pfam05902
      Location:694 → 800
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)
      pfam09379
      Location:215 → 275
      FERM_N; FERM N-terminal domain

    2. NM_001128607.2 → NP_001122079.1  protein 4.1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple in-frame exons, uses an alternate 5' splice site, and uses a different 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream ATG and an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AL607088, AL669981
      Consensus CDS
      CCDS89834.1
      UniProtKB/TrEMBL
      A0A571BEG4, A2A838
      Related
      ENSMUSP00000158714.2, ENSMUST00000146021.8
      Conserved Domains (7) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:87 → 192
      FERM_M; FERM central domain
      pfam04382
      Location:399 → 443
      SAB; SAB domain
      pfam05902
      Location:484 → 590
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)
      pfam09379
      Location:5 → 65
      FERM_N; FERM N-terminal domain

    3. NM_183428.3 → NP_906273.3  protein 4.1 isoform 1

      See identical proteins and their annotated locations for NP_906273.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK220462, AL669981, CB526050, CB723734, CN526385, CN537562
      Consensus CDS
      CCDS18717.1
      UniProtKB/Swiss-Prot
      A2A843, P48193, Q5DTQ8, Q68FF1, Q6NVF5
      UniProtKB/TrEMBL
      A2A841
      Related
      ENSMUSP00000030739.5, ENSMUST00000030739.11
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:662 → 709
      SAB; SAB domain
      pfam05902
      Location:748 → 854
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      131650724..131802824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320238.3 → XP_017175727.1  protein 4.1 isoform X12

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:399 → 445
      SAB; SAB domain
      pfam05902
      Location:634 → 740
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    2. XM_036164149.1 → XP_036020042.1  protein 4.1 isoform X24

      UniProtKB/TrEMBL
      A2A838
      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:399 → 445
      SAB; SAB domain
      pfam05902
      Location:496 → 602
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 333
      FA; FERM adjacent (FA)

    3. XM_006538901.5 → XP_006538964.2  protein 4.1 isoform X10

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:399 → 445
      SAB; SAB domain
      pfam05902
      Location:651 → 757
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    4. XM_017320241.3 → XP_017175730.1  protein 4.1 isoform X23

      UniProtKB/TrEMBL
      A0A068WAZ7, A2A838
      Related
      ENSMUSP00000123623.2, ENSMUST00000137846.8
      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:419 → 466
      SAB; SAB domain
      pfam05902
      Location:505 → 611
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    5. XM_017320237.3 → XP_017175726.1  protein 4.1 isoform X9

      UniProtKB/TrEMBL
      A0A068WAQ5, A2A838
      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:419 → 466
      SAB; SAB domain
      pfam05902
      Location:655 → 761
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    6. XM_036164147.1 → XP_036020040.1  protein 4.1 isoform X21

      UniProtKB/TrEMBL
      A2A838
      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:418 → 466
      SAB; SAB domain
      pfam05902
      Location:517 → 623
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 333
      FA; FERM adjacent (FA)

    7. XM_036164143.1 → XP_036020036.1  protein 4.1 isoform X8

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:418 → 466
      SAB; SAB domain
      pfam05902
      Location:667 → 773
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 333
      FA; FERM adjacent (FA)

    8. XM_006538899.5 → XP_006538962.2  protein 4.1 isoform X6

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:419 → 466
      SAB; SAB domain
      pfam05902
      Location:672 → 778
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    9. XM_006538910.5 → XP_006538973.2  protein 4.1 isoform X20

      UniProtKB/TrEMBL
      A2A838
      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:433 → 480
      SAB; SAB domain
      pfam05902
      Location:519 → 625
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    10. XM_006538909.5 → XP_006538972.2  protein 4.1 isoform X19

      UniProtKB/TrEMBL
      A2A838
      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:438 → 485
      SAB; SAB domain
      pfam05902
      Location:524 → 630
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    11. XM_006538896.5 → XP_006538959.2  protein 4.1 isoform X4

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:438 → 485
      SAB; SAB domain
      pfam05902
      Location:691 → 797
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    12. XM_006538908.5 → XP_006538971.2  protein 4.1 isoform X17

      UniProtKB/TrEMBL
      A2A838
      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:452 → 499
      SAB; SAB domain
      pfam05902
      Location:538 → 644
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    13. XM_006538897.5 → XP_006538960.2  protein 4.1 isoform X5

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:452 → 499
      SAB; SAB domain
      pfam05902
      Location:688 → 794
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    14. XM_036164145.1 → XP_036020038.1  protein 4.1 isoform X16

      UniProtKB/TrEMBL
      A2A838
      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:451 → 499
      SAB; SAB domain
      pfam05902
      Location:550 → 656
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 333
      FA; FERM adjacent (FA)

    15. XM_006538895.5 → XP_006538958.2  protein 4.1 isoform X3

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:452 → 499
      SAB; SAB domain
      pfam05902
      Location:700 → 806
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    16. XM_006538893.5 → XP_006538956.2  protein 4.1 isoform X1

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:452 → 499
      SAB; SAB domain
      pfam05902
      Location:705 → 811
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    17. XM_006538912.5 → XP_006538975.2  protein 4.1 isoform X25

      UniProtKB/TrEMBL
      A2A838
      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:398 → 444
      SAB; SAB domain
      pfam05902
      Location:483 → 589
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    18. XM_006538902.5 → XP_006538965.2  protein 4.1 isoform X11

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:398 → 444
      SAB; SAB domain
      pfam05902
      Location:650 → 756
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    19. XM_006538900.5 → XP_006538963.2  protein 4.1 isoform X7

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:418 → 465
      SAB; SAB domain
      pfam05902
      Location:671 → 777
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    20. XM_006538894.5 → XP_006538957.2  protein 4.1 isoform X2

      Conserved Domains (5) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:451 → 498
      SAB; SAB domain
      pfam05902
      Location:704 → 810
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    21. XM_017320243.2 → XP_017175732.1  protein 4.1 isoform X36

      UniProtKB/TrEMBL
      A2A842
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:608 → 654
      SAB; SAB domain
      pfam05902
      Location:693 → 799
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)

    22. XM_036164155.1 → XP_036020048.1  protein 4.1 isoform X35

      UniProtKB/TrEMBL
      B6ZHC8
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:627 → 675
      SAB; SAB domain
      pfam05902
      Location:714 → 820
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    23. XM_036164151.1 → XP_036020044.1  protein 4.1 isoform X31

      UniProtKB/TrEMBL
      A2A841
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:660 → 708
      SAB; SAB domain
      pfam05902
      Location:747 → 853
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    24. XM_036164144.1 → XP_036020037.1  protein 4.1 isoform X14

      UniProtKB/TrEMBL
      A2A841
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:660 → 708
      SAB; SAB domain
      pfam05902
      Location:914 → 1020
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    25. XM_036164148.1 → XP_036020041.1  protein 4.1 isoform X22

      UniProtKB/TrEMBL
      B6ZHC8
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:609 → 655
      SAB; SAB domain
      pfam05902
      Location:844 → 950
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    26. XM_036164146.1 → XP_036020039.1  protein 4.1 isoform X18

      UniProtKB/TrEMBL
      B6ZHC8
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:609 → 655
      SAB; SAB domain
      pfam05902
      Location:861 → 967
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    27. XM_036164154.1 → XP_036020047.1  protein 4.1 isoform X34

      UniProtKB/TrEMBL
      B6ZHC8
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:628 → 676
      SAB; SAB domain
      pfam05902
      Location:715 → 821
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    28. XM_030253586.2 → XP_030109446.1  protein 4.1 isoform X30

      UniProtKB/Swiss-Prot
      A2A843, P48193, Q5DTQ8, Q68FF1, Q6NVF5
      UniProtKB/TrEMBL
      A2A841
      Related
      ENSMUSP00000101601.3, ENSMUST00000105981.9
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:662 → 709
      SAB; SAB domain
      pfam05902
      Location:748 → 854
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)

    29. XM_006538907.5 → XP_006538970.1  protein 4.1 isoform X13

      UniProtKB/TrEMBL
      A2A841
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:662 → 709
      SAB; SAB domain
      pfam05902
      Location:915 → 1021
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)

    30. XM_017320239.1 → XP_017175728.1  protein 4.1 isoform X15

      UniProtKB/TrEMBL
      A2A841
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:648 → 695
      SAB; SAB domain
      pfam05902
      Location:901 → 1007
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 542
      FA; FERM adjacent (FA)

    31. XM_036164150.1 → XP_036020043.1  protein 4.1 isoform X29

      UniProtKB/TrEMBL
      A2A841
      Conserved Domains (5) summary
      smart00295
      Location:212 → 402
      B41; Band 4.1 homologues
      cd13184
      Location:397 → 490
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:661 → 709
      SAB; SAB domain
      pfam05902
      Location:760 → 866
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:500 → 543
      FA; FERM adjacent (FA)

    32. XM_036164152.1 → XP_036020045.1  protein 4.1 isoform X32

      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:399 → 445
      SAB; SAB domain
      pfam08736
      Location:290 → 333
      FA; FERM adjacent (FA)

    33. XM_006538916.5 → XP_006538979.2  protein 4.1 isoform X28

      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:452 → 499
      SAB; SAB domain
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    34. XM_006538915.5 → XP_006538978.2  protein 4.1 isoform X27

      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:452 → 499
      SAB; SAB domain
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    35. XM_006538913.5 → XP_006538976.2  protein 4.1 isoform X26

      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:452 → 499
      SAB; SAB domain
      pfam08736
      Location:290 → 332
      FA; FERM adjacent (FA)

    36. XM_036164153.1 → XP_036020046.1  protein 4.1 isoform X33

      Conserved Domains (4) summary
      smart00295
      Location:2 → 192
      B41; Band 4.1 homologues
      cd13184
      Location:187 → 280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:398 → 444
      SAB; SAB domain
      pfam08736
      Location:290 → 333
      FA; FERM adjacent (FA)

    37. XM_036164159.1 → XP_036020052.1  protein 4.1 isoform X40

      UniProtKB/TrEMBL
      A2AD32
      Conserved Domains (4) summary
      smart00295
      Location:222 → 412
      B41; Band 4.1 homologues
      cd13184
      Location:407 → 500
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:670 → 718
      SAB; SAB domain
      pfam08736
      Location:510 → 553
      FA; FERM adjacent (FA)

    38. XM_036164157.1 → XP_036020050.1  protein 4.1 isoform X38

      UniProtKB/TrEMBL
      A2AD32
      Conserved Domains (4) summary
      smart00295
      Location:222 → 412
      B41; Band 4.1 homologues
      cd13184
      Location:407 → 500
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:670 → 718
      SAB; SAB domain
      pfam08736
      Location:510 → 553
      FA; FERM adjacent (FA)

    39. XM_036164160.1 → XP_036020053.1  protein 4.1 isoform X41

      UniProtKB/TrEMBL
      A2AD32
      Conserved Domains (4) summary
      smart00295
      Location:222 → 412
      B41; Band 4.1 homologues
      cd13184
      Location:407 → 500
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:619 → 665
      SAB; SAB domain
      pfam08736
      Location:510 → 553
      FA; FERM adjacent (FA)

    40. XM_036164158.1 → XP_036020051.1  protein 4.1 isoform X39

      UniProtKB/TrEMBL
      A2AD32
      Conserved Domains (4) summary
      smart00295
      Location:222 → 412
      B41; Band 4.1 homologues
      cd13184
      Location:407 → 500
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:671 → 719
      SAB; SAB domain
      pfam08736
      Location:510 → 553
      FA; FERM adjacent (FA)

    41. XM_036164156.1 → XP_036020049.1  protein 4.1 isoform X37

      UniProtKB/TrEMBL
      A2AD32
      Related
      ENSMUSP00000120236.3, ENSMUST00000141291.3
      Conserved Domains (4) summary
      smart00295
      Location:222 → 412
      B41; Band 4.1 homologues
      cd13184
      Location:407 → 500
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:671 → 719
      SAB; SAB domain
      pfam08736
      Location:510 → 553
      FA; FERM adjacent (FA)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48193.2 GenPept UniProtKB/Swiss-Prot:P48193

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