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    Slk STE20-like kinase [ Mus musculus (house mouse) ]

    Gene ID: 20874, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slkprovided by MGI
    Official Full Name
    STE20-like kinaseprovided by MGI
    Primary source
    MGI:MGI:103241
    See related
    Ensembl:ENSMUSG00000025060 AllianceGenome:MGI:103241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9A2; Etk4; SMAK; Stk2; mSLK; mKIAA0204
    Summary
    Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Involved in regulation of cell migration. Located in cell leading edge. Is expressed in several structures, including alimentary system; eye; genitourinary system; muscle tissue; and nervous system. Orthologous to human SLK (STE20 like kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.8), placenta adult (RPKM 11.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3- D1; 19 39.77 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47568458..47633685)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47580019..47645246)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46363 Neighboring gene predicted gene, 41858 Neighboring gene STN1, CST complex subunit Neighboring gene predicted gene, 19557 Neighboring gene STARR-positive B cell enhancer ABC_E5709 Neighboring gene STARR-seq mESC enhancer starr_46366 Neighboring gene predicted gene 16068 Neighboring gene collagen, type XVII, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_46367 Neighboring gene predicted gene, 26085

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ste20-like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes. Song K, et al. Cell Prolif, 2023 Apr. PMID 36579845, Free PMC Article
    2. Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy. Schoch S, et al. J Neurosci, 2021 Sep 29. PMID 34400520, Free PMC Article
    3. Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers. Al-Zahrani KN, et al. Oncogene, 2020 Jun. PMID 32393835
    4. Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice. Woychyshyn B, et al. Am J Physiol Renal Physiol, 2020 Jun 1. PMID 32308020
    5. Ste20-like kinase, SLK, a novel mediator of podocyte integrity. Cybulsky AV, et al. Am J Physiol Renal Physiol, 2018 Jul 1. PMID 29187370, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of the Ste20-like kinase SLK in podocyte adhesion.
      Title: Role of the Ste20-like kinase SLK in podocyte adhesion.
    2. Ste20-like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes.
      Title: Ste20-like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes.
    3. Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy.
      Title: Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy.
    4. Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.
      Title: Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.
    5. Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers.
      Title: Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers.
    6. Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice.
      Title: Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice.
    7. Podocyte-specific deletion of SLK leads to albuminuria, loss of podocytes, and morphological evidence of podocyte injury. Thus, SLK is essential to the maintenance of podocyte integrity.
      Title: Ste20-like kinase, SLK, a novel mediator of podocyte integrity.
    8. Loss of SLK impairs myofiber stability and function.
      Title: Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.
    9. kinases, including Slk, Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
      Title: A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.
    10. activation of SLK by haptotactic signals requires its recruitment to the leading edge by LMO4 in a Src-dependent manner.
      Title: Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    STE20-like serine/threonine-protein kinase
    Names
    STE20-related kinase SMAK
    STE20-related serine/threonine-protein kinase
    serine/threonine-protein kinase 2
    NP_001158111.1
    NP_033315.2
    XP_006526890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164639.1 → NP_001158111.1  STE20-like serine/threonine-protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001158111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC125075, AK029491, AK037798, AK051969, CD740818, CO431234
      Consensus CDS
      CCDS50465.1
      UniProtKB/TrEMBL
      A2RRK3
      Related
      ENSMUSP00000026043.6, ENSMUST00000026043.12
      Conserved Domains (3) summary
      smart00220
      Location:34 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28 → 309
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:987 → 1127
      PKK; Polo kinase kinase

    2. NM_009289.3 → NP_033315.2  STE20-like serine/threonine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_033315.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125075, AK029491, AK037798, AK051969, CA535951, CD740818, CF748583, CO431234
      Consensus CDS
      CCDS38017.1
      UniProtKB/Swiss-Prot
      A2RRK4, O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41
      Related
      ENSMUSP00000049977.8, ENSMUST00000051691.8
      Conserved Domains (3) summary
      smart00220
      Location:34 → 292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28 → 309
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:1018 → 1158
      PKK; Polo kinase kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47568458..47633685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526827.5 → XP_006526890.1  STE20-like serine/threonine-protein kinase isoform X1

      Conserved Domains (3) summary
      PTZ00121
      Location:284 → 1112
      PTZ00121; MAEBL; Provisional
      pfam12474
      Location:942 → 1082
      PKK; Polo kinase kinase
      cl21453
      Location:1 → 233
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54988.2 GenPept UniProtKB/Swiss-Prot:O54988

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